News & Views |
Featured
-
-
Article |
Accurate computational design of three-dimensional protein crystals
The process of protein crystallization is poorly understood and difficult to program through the primary sequence. Here the authors develop a computational approach to designing three-dimensional protein crystals with prespecified lattice architectures with high accuracy.
- Zhe Li
- , Shunzhi Wang
- & David Baker
-
Editorial |
Ascent of machine learning in medicine
Machine learning is swiftly infiltrating many areas within the healthcare industry, from diagnosis and prognosis to drug development and epidemiology, with significant potential to transform the medical landscape.
-
Comment |
Avoiding common pitfalls in machine learning omic data science
This Comment describes some of the common pitfalls encountered in deriving and validating predictive statistical models from high-dimensional data. It offers a fresh perspective on some key statistical issues, providing some guidelines to avoid pitfalls, and to help unfamiliar readers better assess the reliability and significance of their results.
- Andrew E. Teschendorff
-
News & Views |
Treasure trove for cancer medicine
Fragments of DNA that are derived from dead tumour cells and shed into a patient's blood have been utilized as biomarkers for the diagnosis and prognosis of liver cancer.
- Miljana Tanić
- & Stephan Beck
-
News & Views |
A candidate magnetoreceptor
A protein complex found to align with the direction of a magnetic field could be a key piece in the puzzle of how animals detect magnetic fields.
- Kenneth J. Lohmann
-
News & Views |
Encoding phase transitions
Intrinsically disordered protein polymers can be designed to encode tunable lower or upper critical solution temperatures in physiological solutions.
- Alex S. Holehouse
- & Rohit V. Pappu
Browse broader subjects
Browse narrower subjects
- Biochemical reaction networks
- Cellular signalling networks
- Classification and taxonomy
- Communication and replication
- Computational models
- Computational neuroscience
- Computational platforms and environments
- Data acquisition
- Data integration
- Data mining
- Data processing
- Data publication and archiving
- Databases
- Functional clustering
- Gene ontology
- Gene regulatory networks
- Genome informatics
- Hardware and infrastructure
- High-throughput screening
- Image processing
- Literature mining
- Machine learning
- Microarrays
- Network topology
- Phylogeny
- Power law
- Predictive medicine
- Probabilistic data networks
- Programming language
- Protein analysis
- Protein design
- Protein folding
- Protein function predictions
- Protein structure predictions
- Proteome informatics
- Quality control
- Scale invariance
- Sequence annotation
- Software
- Standards
- Statistical methods
- Virtual drug screening