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| Open AccessCymoxanil disrupts RNA synthesis through inhibiting the activity of dihydrofolate reductase
- Thomas David Daniel Kazmirchuk
- , Daniel. J. Burnside
- & Ashkan Golshani
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| Open AccessNetwork analysis of the proteome and peptidome sheds light on human milk as a biological system
- Pieter M. Dekker
- , Sjef Boeren
- & Kasper A. Hettinga
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| Open AccessThe impact of selected xanthophylls on oil hydrolysis by pancreatic lipase: in silico and in vitro studies
- Grzegorz Dąbrowski
- , Sylwester Czaplicki
- & Iwona Konopka
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| Open AccessExploring the hemicellulolytic properties and safety of Bacillus paralicheniformis as stepping stone in the use of new fibrolytic beneficial microbes
- Serigne Inssa Ngom
- , Soufiane Maski
- & Christel Béra-Maillet
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| Open AccessStructural insights into N-terminal methionine cleavage by the human mitochondrial methionine aminopeptidase, MetAP1D
- Yeon Lee
- , Hayoung Kim
- & Hyoun Sook Kim
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| Open AccessEnzyme mechanistic studies of NMA1982, a protein tyrosine phosphatase and potential virulence factor in Neisseria meningitidis
- Shuangding Wu
- , Mathieu Coureuil
- & Lutz Tautz
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| Open AccessInhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches
- Apramita Devi
- , Morris Levin
- & Andrew L. Waterhouse
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| Open AccessIdentification and characterization of a novel heparinase PCHepII from marine bacterium Puteibacter caeruleilacunae
- Danrong Lu
- , Luping Wang
- & Qingdong Zhang
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| Open AccessDiscovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation
- Honami Echizen
- , Kenjiro Hanaoka
- & Yasuteru Urano
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| Open AccessBiochemical analysis of Komagataella phaffii oxidative folding proposes novel regulatory mechanisms of disulfide bond formation in yeast
- Arianna Palma
- , Lukas A. Rettenbacher
- & Lloyd Ruddock
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| Open AccessModified polysulfone membrane facilitates rapid separation of plasma from whole blood for an effective anti-SARS-CoV-2-IgM diagnosis
- Maryam Ijadi Bajestani
- & Hossein Ahmadzadeh
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| Open AccessAmino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1
- Fangfang Chen
- , Israfil Yalcin
- & Konrad Büssow
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| Open AccessCannabis sativa-based oils against aluminum-induced neurotoxicity
- Carla Alves
- , Wagner Antonio Tamagno
- & Leonardo José Gil Barcellos
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Article
| Open AccessHuman soluble CD39 displays substrate inhibition in a substrate-specific manner
- Venkat M. K. Vadlamani
- , Kavinda K. J. Gunasinghe
- & Matthew T. Harper
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| Open AccessH2O2 selectively damages the binuclear iron-sulfur cluster N1b of respiratory complex I
- Lisa Strotmann
- , Caroline Harter
- & Thorsten Friedrich
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| Open AccessMechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition
- Laurent Le Corre
- & Dominique Padovani
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| Open AccessThe thiolation of uridine 34 in tRNA, which controls protein translation, depends on a [4Fe-4S] cluster in the archaeum Methanococcus maripaludis
- Ornella Bimai
- , Pierre Legrand
- & Béatrice Golinelli-Pimpaneau
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| Open AccessUtilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
- Hezi Hayun
- , Matt Coban
- & Niv Papo
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Article
| Open AccessCoenzyme A binding sites induce proximal acylation across protein families
- Chris Carrico
- , Andrew Cruz
- & Eric Verdin
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| Open AccessIn silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor
- Asma Gholami
- , Dariush Minai-Tehrani
- & Leif A. Eriksson
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| Open AccessMagnetic field and nuclear spin influence on the DNA synthesis rate
- Sergey V. Stovbun
- , Dmitry V. Zlenko
- & Anatoly L. Buchachenko
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| Open AccessLive imaging of apoptotic signaling flow using tunable combinatorial FRET-based bioprobes for cell population analysis of caspase cascades
- Miho Suzuki
- , Yutaka Shindo
- & Kotaro Oka
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| Open AccessMechanistic investigation of SARS-CoV-2 main protease to accelerate design of covalent inhibitors
- Hoshin Kim
- , Darin Hauner
- & Neeraj Kumar
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| Open AccessIn vitro biochemical assessment of mixture effects of two endocrine disruptors on INS-1 cells
- Lamidi W. B. Olaniyan
- & Anthony I. Okoh
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| Open AccessA critical path to producing high quality, reproducible data from quantitative western blot experiments
- Sean C. Taylor
- , Luciana K. Rosselli-Murai
- & Isabelle Plante
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| Open AccessVanillin reduction in the biosynthetic pathway of capsiate, a non-pungent component of Capsicum fruits, is catalyzed by cinnamyl alcohol dehydrogenase
- Kaori Sano
- , Yuya Uzawa
- & Kenji Kobata
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| Open AccessElectrostatic interactions between single arginine and phospholipids modulate physiological properties of sarcoplasmic reticulum Ca2+-ATPase
- Kazuo Yamasaki
- , Takashi Daiho
- & Hiroshi Suzuki
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| Open AccessStructure and function of cancer-related developmentally regulated GTP-binding protein 1 (DRG1) is conserved between sponges and humans
- Silvestar Beljan
- , Kristina Dominko
- & Helena Ćetković
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| Open AccessSubstrate-dependent modulation of the leukotriene A4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation
- Kyung Hyeon Lee
- , Nadia Fazal Ali
- & Mikell Paige
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| Open AccessFirst crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
- Robin M. Gierse
- , Rick Oerlemans
- & Matthew R. Groves
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| Open AccessRandomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores
- Donogh Maguire
- , Alana Burns
- & Donald C. McMillan
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| Open AccessQueueing theory model of pentose phosphate pathway
- Sylwester M. Kloska
- , Krzysztof Pałczyński
- & Tadeusz A. Wysocki
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| Open AccessNematicidal activity of seaweed-synthesized silver nanoparticles and extracts against Meloidogyne incognita on tomato plants
- Rehab Y. Ghareeb
- , Nihal Galal El-Din Shams El-Din
- & Nader R. Abdelsalam
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| Open AccessThe ACE genes in Aphelenchoides besseyi isolates and their expression correlation to the fenamiphos treatment
- Jung-Kai Hsu
- , Chia-Wei Weng
- & Peichen Janet Chen
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| Open AccessComprehensive characterization and molecular insights into the salt tolerance of a Cu, Zn-superoxide dismutase from an Indian Mangrove, Avicennia marina
- Rajat Kanti Sarkar
- , Moumita Bhowmik
- & Kashinath Bhattacharya
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| Open AccessPro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19
- Kodai Abe
- , Yasuaki Kabe
- & Kenjiro Kosaki
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| Open AccessBiochemical and structural characterization of quizalofop-resistant wheat acetyl-CoA carboxylase
- Raven Bough
- & Franck E. Dayan
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| Open AccessKinetic control of nascent protein biogenesis by peptide deformylase
- Lena A. K. Bögeholz
- , Evan Mercier
- & Marina V. Rodnina
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| Open AccessThe encapsulin from Thermotoga maritima is a flavoprotein with a symmetry matched ferritin-like cargo protein
- Benjamin J. LaFrance
- , Caleb Cassidy-Amstutz
- & David F. Savage
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| Open Accessβ-elimination of hyaluronate by red king crab hyaluronidase
- Dmitrii Sliadovskii
- , Tatyana Ponomareva
- & Evgeny Sogorin
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| Open AccessAssessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase
- Tena Čadež
- , Dora Kolić
- & Zrinka Kovarik
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| Open AccessIdentification of the first highly selective inhibitor of human lactate dehydrogenase B
- Sachio Shibata
- , Satoshi Sogabe
- & Tomoyoshi Soga
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| Open AccessPrevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia
- Shirli Tay
- , Gayan S. De Silva
- & Mohamed A. Zayed
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| Open AccessRedox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability
- Judit Eszter Szabó
- , Kinga Nyíri
- & Beáta Vértessy
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| Open AccessRevealing Escherichia coli type II l-asparaginase active site flexible loop in its open, ligand-free conformation
- Maristella Maggi
- , Massimiliano Meli
- & Claudia Scotti
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| Open AccessMultibiomarker responses to polycyclic aromatic hydrocarbons and microplastics in thumbprint emperor Lethrinus harak from a South Pacific locally managed marine area
- Rufino Varea
- , Andrew Paris
- & Susanna Piovano
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| Open AccessRevealing the molecular interplay of curcumin as Culex pipiens Acetylcholine esterase 1 (AChE1) inhibitor
- Priyashi Rao
- , Dweipayan Goswami
- & Rakesh M. Rawal
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| Open AccessThe ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I
- George Mavridis
- , Anastasia Mpakali
- & Efstratios Stratikos
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| Open AccessStructural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis
- Woo Cheol Lee
- , Sungjae Choi
- & Yangmee Kim