Innate immunity articles from across Nature Portfolio

Latest Research and Reviews

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  DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways

  Here, Rongbin Zhou and colleagues review the different types of damage-associated molecular pattern (DAMP) that trigger sterile inflammation via pattern recognition receptors. The authors group these DAMPs on the basis of whether they arise from inside cells, from neighbouring cells or from distant tissues, and they discuss the relevance of such DAMPs in various inflammatory disease settings.

  • Yi Huang
  • Wei Jiang
  • Rongbin Zhou

  Reviews29 Apr 2024 Nature Reviews Immunology

  P: 1-17
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  Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3

  Oxygen is an essential requirement for aerobic organisms. Here the authors explore the role of oxygen in the antiviral innate response in multiple models of infection and suggest oxygen enhances the antiviral innate response via EGLN1 hydroxylation of IRF3.

  • Xing Liu
  • Jinhua Tang
  • Wuhan Xiao

  ResearchOpen Access26 Apr 2024 Nature Communications

  Volume: 15, P: 3533
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  An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission

  Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus with unclear immune cell involvement. Here the authors generate a single cell transcriptomic dataset with 400k cells from the esophageal mucosa of active EoE patients, remission EoE patients, and healthy individuals to characterise esophageal cellular composition, phenotype and interaction in this disease.

  • Jiarui Ding
  • John J. Garber
  • Ramnik J. Xavier

  ResearchOpen Access18 Apr 2024 Nature Communications

  Volume: 15, P: 3344
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  SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

  • Chiu Wang Chau
  • Alex To
  • Ryohichi Sugimura

  ResearchOpen Access16 Apr 2024 Scientific Reports

  Volume: 14, P: 8781
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  Molecular biomarker approaches to prevention of post-traumatic osteoarthritis

  Early identification of osteoarthritis (OA) prior to the development of symptoms is challenging. Post-traumatic OA provides a model for the development of OA following a defined event. In this Review, the authors describe the existing knowledge relating to the biomarkers of post-traumatic OA, which might also be applicable to the identification of early non-traumatic OA.

  • Virginia Byers Kraus
  • Ming-Feng Hsueh

  Reviews11 Apr 2024 Nature Reviews Rheumatology

  Volume: 20, P: 272-289

• ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D

  • Gang Du
  • Liam B. Healy
  • Hao Wu

  Research10 Apr 2024 Nature

  P: 1-3