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| Open AccessSynthesis and molecular docking studies of new aryl imeglimin derivatives as a potent antidiabetic agent in a diabetic zebrafish model
- Aylin Khodakhah
- , Hassan Mohammadi
- & Massoud Amanlou
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| Open AccessEssential oil composition, morphological characterization, phenolic content and antioxidant activity of Iranian populations of Hymenocrater longiflorus Benth. (Lamiaceae)
- Basireh Fattahpour
- , Mohammad Fattahi
- & Abbas Hassani
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| Open AccessHigher level of physical activity reduces mental and neurological symptoms during and two years after COVID-19 infection in young women
- Johanna Takács
- , Darina Deák
- & Akos Koller
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| Open AccessLC/MS/MS and GC/MS/MS metabolic profiling of Leontodon hispidulus, in vitro and in silico anticancer activity evaluation targeting hexokinase 2 enzyme
- Noha Mokhtar Abd-El-Aziz
- , Mohamed Saeed Hifnawy
- & Inas Youssef Younis
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| Open AccessTHOUSAND-GRAIN WEIGHT 6, which is an IAA-glucose hydrolase, preferentially recognizes the structure of the indole ring
- Tatsuki Akabane
- , Nobuhiro Suzuki
- & Naoki Hirotsu
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| Open AccessFlavor characteristics of garlic fish cakes using electronic nose and tongue analyses
- Hae-Yeon Choi
- , Hye-Eun Woo
- & Jin-Hee Choi
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| Open AccessLC–MS profiling, in vitro and in silico C-ABL kinase inhibitory approach to identify potential anticancer agents from Dalbergia sissoo leaves
- Hem N. Naik
- , Dilip Kanjariya
- & Smita Jauhari
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| Open AccessHigh-throughput ligand profile characterization in novel cell lines expressing seven heterologous insect olfactory receptors for the detection of volatile plant biomarkers
- Katalin Zboray
- , Adam V. Toth
- & Peter Lukacs
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| Open Access1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors
- Maurício T. Tavares
- , Arne Krüger
- & Roberto Parise-Filho
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| Open AccessAntioxidant and α-glucosidase inhibitory activities of compound isolated from Stachytarpheta jamaicensis (L) Vahl. leaves
- Sri Fatmawati
- , Fithrotul Auwaliyah
- & Muhammad Iqbal Choudhary
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| Open AccessComparison of antithrombin activity assays in detection of patients with heparin binding site antithrombin deficiency: systematic review and meta-analysis
- Tamara Rojnik
- , Nataša Sedlar
- & Mojca Božič Mijovski
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| Open AccessSimultaneous determination of 2-(3-hydroxy-5-phosphonooxymethyl-2-methyl-4-pyridyl)-1,3-thiazolidine-4-carboxylic acid and main plasma aminothiols by HPLC–UV based method
- Justyna Piechocka
- , Monika Wyszczelska-Rokiel
- & Rafał Głowacki
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| Open AccessModulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
- Frances M. Bashore
- , Ariana B. Marquez
- & Alison D. Axtman
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| Open AccessDesign and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis
- Mohamed A. Elanany
- , Essam Eldin A. Osman
- & Sahar M. Abou-Seri
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| Open AccessIdentifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches
- Leah Amod
- , Roxanne Mohunlal
- & Kathryn J. Wicht
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| Open AccessAn open-source smartphone app for the quantitative evaluation of thin-layer chromatographic analyses in medicine quality screening
- Cathrin Hauk
- , Mark Boss
- & Lutz Heide
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| Open AccessOptimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform
- Andrew A. Bieberich
- , Tuomo Laitinen
- & Christopher R. M. Asquith
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Article
| Open AccessColloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor
- Ivana Šišoláková
- , Ondrej Petruš
- & Renáta Oriňaková
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Article
| Open AccessAppraisal of growth inhibitory, biochemical and genotoxic effects of Allyl Isothiocyanate on different developmental stages of Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae)
- Sumit Singh
- , Diksha
- & Satwinder Kaur Sohal
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| Open AccessYeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs)
- M. Meltzer
- , T. Zvagelsky
- & Stanislav Engel
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| Open AccessImprovement in sensitivity for lateral flow immunoassay of ferritin using novel device design based on gold-enhanced gold nanoparticles
- Pattarachaya Preechakasedkit
- , Kanyapat Teekayupak
- & Nipapan Ruecha
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| Open AccessDecoding the protein–ligand interactions using parallel graph neural networks
- Carter Knutson
- , Mridula Bontha
- & Neeraj Kumar
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| Open AccessComprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay
- Alexander Medvedev
- , Matt Moeser
- & Sergei S. Makarov
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Article
| Open AccessDesign, synthesis and evaluation of novel 2-oxoindoline-based acetohydrazides as antitumor agents
- Do T. M. Dung
- , Eun J. Park
- & Nguyen-Hai Nam
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| Open AccessNon-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits
- Giacomo G. Rossetti
- , Marianna A. Ossorio
- & Thanos D. Halazonetis
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| Open AccessEstablishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1
- Kaizhao Hu
- , Xiao-Jing Li
- & Hong-Min Liu
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| Open AccessCharacterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening
- Hannah M. Work
- , Sylvie E. Kandel
- & Jed N. Lampe
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| Open AccessScreening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation
- Erik M. K. Rasmussen
- , Kristine L. Seier
- & John Arne Dahl
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| Open AccessHumidifier disinfectant, sodium dichloroisocyanurate (NaDCC): assessment of respiratory effects to protect workers’ health
- DongSeok Seo
- , Yong-Hoon Lee
- & JiMin Jo
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| Open AccessSmall molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers
- Martina Meßner
- , Melanie M. Mandl
- & Johanna Pachmayr
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| Open AccessA survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics
- Jessica Knox
- , Nicolas Joly
- & Peter J. Roy
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| Open AccessMultisubstituted pyrimidines effectively inhibit bacterial growth and biofilm formation of Staphylococcus aureus
- Riccardo Provenzani
- , Paola San-Martin-Galindo
- & Jari Yli-Kauhaluoma
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| Open AccessIdentification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein–protein interaction-oriented library and machine learning
- Yugo Shimizu
- , Tomoki Yonezawa
- & Kazuyoshi Ikeda
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| Open AccessIdentification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2
- Ewelina Weglarz-Tomczak
- , Jakub M. Tomczak
- & Stanley Brul
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| Open AccessA high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics
- Anthony D. Verderosa
- , Rabeb Dhouib
- & Makrina Totsika
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| Open AccessHigh-throughput screening to discover inhibitors of the CarD·RNA polymerase protein–protein interaction in Mycobacterium tuberculosis
- Maxwell A. Stefan
- , Glory M. Velazquez
- & George A. Garcia
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| Open AccessPharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer
- Reid T. Powell
- , Abena Redwood
- & Helen Piwnica-Worms
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| Open AccessSolution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches
- John F. Darby
- , Lewis R. Vidler
- & Paul Workman
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| Open AccessPKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor
- Tigist Y. Tamir
- , David H. Drewry
- & Alison D. Axtman
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| Open AccessA membrane transporter determines the spectrum of activity of a potent platinum–acridine hybrid anticancer agent
- Xiyuan Yao
- , Noah H. Watkins
- & Ulrich Bierbach
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| Open AccessAn engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTA
- Nishant Mehta
- , Sainiteesh Maddineni
- & Jennifer R. Cochran
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| Open AccessAmygdalin based G-6-P synthase inhibitors as novel preservatives for food and pharmaceutical products
- Amit Lather
- , Sunil Sharma
- & Anurag Khatkar
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| Open AccessA FRET-based screening method to detect potential inhibitors of the binding of CNNM3 to PRL2
- Faji Cai
- , Yichen Huang
- & Motoyuki Hattori
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Article
| Open AccessDREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1
- Shuo Zhou
- , Ziyuan Zhou
- & Chang-Guo Zhan
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| Open AccessGene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes
- Steffen Renner
- , Christian Bergsdorf
- & Pierre Farmer
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| Open AccessVenturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics
- Venkateswarlu Yarlagadda
- , Ricardo Medina
- & Gerard D. Wright
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| Open AccessDigital DNA microarray generation on glass substrates
- Johannes Wöhrle
- , Stefan D. Krämer
- & Günter Roth
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| Open AccessHigh-Throughput Screening to Predict Chemical-Assay Interference
- Alexandre Borrel
- , Ruili Huang
- & Nicole C. Kleinstreuer
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| Open AccessVirtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites
- Ana Carolina C. de Sousa
- , Jill M. Combrinck
- & Timothy J. Egan