Featured
-
-
Article
| Open AccessDisruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC
- Sean F. Cooke
- , Thomas A. Wright
- & Connor M. Blair
-
Article
| Open AccessA highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model
- Lauren M. Weaver
- , Madeline J. Stewart
- & Chang-Guo Zhan
-
Article
| Open AccessThe novel drug candidate S2/IAPinh improves survival in models of pancreatic and ovarian cancer
- Takaomi Hagi
- , Suwanna Vangveravong
- & Dirk Spitzer
-
Article
| Open AccessDigital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model
- Radina Kostadinova
- , Simon Ströbel
- & Mathieu Petitjean
-
Article
| Open AccessNetwork pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Radix Astragali against hypopharyngeal carcinoma
- Jianing Zhang
- & Lianhe Li
-
Article
| Open AccessPRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo
- Elizabeth J. Brown
- , Leire Balaguer-Lluna
- & Gillian Farnie
-
Article
| Open AccessNetwork pharmacology-based research on the effect of Radix Astragali on osteosarcoma and the underlying mechanism
- Yafang Zhang
- , Junqiang Wei
- & Yu Jin
-
Article
| Open AccessReduction of retinal ganglion cell death in mouse models of familial dysautonomia using AAV-mediated gene therapy and splicing modulators
- Anastasia Schultz
- , Shun-Yun Cheng
- & Frances Lefcort
-
Article
| Open AccessBinding affinity predictions with hybrid quantum-classical convolutional neural networks
- L. Domingo
- , M. Djukic
- & F. Borondo
-
Article
| Open AccessAnti-methicillin-resistant Staphylococcus aureus activity and safety evaluation of 14-O-[(5-ethoxycarbonyl-4,6-dimethylpyrimidine-2-yl) thioacetyl] mutilin (EDT)
- Yuhang Zhou
- , Yunpeng Yi
- & Ruofeng Shang
-
Article
| Open AccessTamoxifen associated to the conservative CKD treatment promoted additional antifibrotic effects on experimental hypertensive nephrosclerosis
- Camilla Fanelli
- , Ana L. R. Francini
- & Irene L. Noronha
-
Article
| Open AccessMolecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management
- P. C. Agu
- , C. A. Afiukwa
- & P. M. Aja
-
Article
| Open AccessExploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases
- Jan Kägi
- , Willough Sloan
- & Thorsten Friedrich
-
Article
| Open AccessBroad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates
- Wiebke Obermann
- , Mohammad Farhan Darin Azri
- & Gaspar Taroncher-Oldenburg
-
Article
| Open AccessReal-time measurements of vascular permeability in the mouse eye using vitreous fluorophotometry
- Nadine Colé
- , Janina Thoele
- & Richard H. Foxton
-
Article
| Open AccessEbselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase
- Mikolaj Zmudzinski
- , Wioletta Rut
- & Marcin Drag
-
Article
| Open AccessA publication-wide association study (PWAS), historical language models to prioritise novel therapeutic drug targets
- David Narganes-Carlón
- , Daniel J. Crowther
- & Ewan R. Pearson
-
Article
| Open AccessRoles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib
- Kathleen J. Till
- , Mariah Abdullah
- & Joseph R. Slupsky
-
Article
| Open AccessIdentifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches
- Leah Amod
- , Roxanne Mohunlal
- & Kathryn J. Wicht
-
Article
| Open AccessIn silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor
- Asma Gholami
- , Dariush Minai-Tehrani
- & Leif A. Eriksson
-
Article
| Open AccessExpression of membrane Hsp90 is a molecular signature of T cell activation
- Scott A. Scarneo
- , Aaron P. Smith
- & Timothy A. J. Haystead
-
Article
| Open AccessEfficacy of PACE4 pharmacotherapy in JHU-LNCaP-SM preclinical model of androgen independent prostate cancer
- Nawel Mekdad
- , Thi Minh Hue Tran
- & Robert Day
-
Article
| Open AccessOptimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform
- Andrew A. Bieberich
- , Tuomo Laitinen
- & Christopher R. M. Asquith
-
Article
| Open AccessTime and phenotype-dependent transcriptome analysis in AAV-TGFβ1 and Bleomycin-induced lung fibrosis models
- Benjamin Strobel
- , Holger Klein
- & Sebastian Kreuz
-
Article
| Open AccessIrigenin, a novel lead from Iris confusa for management of Helicobacter pylori infection with selective COX-2 and HpIMPDH inhibitory potential
- Passent M. Abdel-Baki
- , Moshera M. El-Sherei
- & Mona M. Okba
-
Article
| Open AccessIn silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19
- Nabih A. Baeshen
- , Abdulaziz O. Albeshri
- & Mohammed N. Baeshen
-
Article
| Open AccessThe K-Ras(G12D)-inhibitory peptide KS-58 suppresses growth of murine CT26 colorectal cancer cell-derived tumors
- Kotaro Sakamoto
- , Bangzhong Lin
- & Shinsaku Nakagawa
-
Article
| Open AccessIdentification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection
- Maria L. Faquetti
- , Francesca Grisoni
- & Andrea M. Burden
-
Article
| Open AccessEfficacy and safety of the sofosbuvir/velpatasvir combination for the treatment of patients with early mild to moderate COVID-19
- Vincenzo Messina
- , Riccardo Nevola
- & Luigi Elio Adinolfi
-
Article
| Open AccessImatinib inhibits SARS-CoV-2 infection by an off-target-mechanism
- Romano Strobelt
- , Julia Adler
- & Yosef Shaul
-
Article
| Open AccessPotential of [11C]UCB-J as a PET tracer for islets of Langerhans
- Emmi Puuvuori
- , Johanna Rokka
- & Olof Eriksson
-
Article
| Open AccessCommon cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells
- Hung Caohuy
- , Ofer Eidelman
- & Harvey B. Pollard
-
Article
| Open AccessEliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers
- Adam J. Davenport
- , Ioana Neagoe
- & Oliver M. Fischer
-
Article
| Open AccessCurcumin inhibited hepatitis B viral entry through NTCP binding
- Piyanoot Thongsri
- , Yongyut Pewkliang
- & Khanit Sa-ngiamsuntorn
-
Article
| Open AccessA forward genetic screen identifies modifiers of rocaglate responsiveness
- Leo Shen
- , Lauren Pugsley
- & Jerry Pelletier
-
Article
| Open AccessEffects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy
- Samantha T. Reyes
- , Robert M. J. Deacon
- & Frederick T. Chin
-
Article
| Open AccessRapid target validation in a Cas9-inducible hiPSC derived kidney model
- Yasaman Shamshirgaran
- , Anna Jonebring
- & Ryan Hicks
-
Article
| Open AccessA phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation
- Sohaib Nizami
- , Val Millar
- & Elena Di Daniel
-
Article
| Open AccessStrictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement
- Atsushi Suzuki
- , Akiyoshi Kunugi
- & Haruhide Kimura
-
Article
| Open AccessSubstrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor
- Michael C. Babcock
- , Christina R. Mikulka
- & Brett E. Crawford
-
Article
| Open AccessImpairing flow-mediated endothelial remodeling reduces extravasation of tumor cells
- Gautier Follain
- , Naël Osmani
- & Jacky G. Goetz
-
Article
| Open AccessA novel piperazine derivative that targets hepatitis B surface antigen effectively inhibits tenofovir resistant hepatitis B virus
- S. Kiruthika
- , Ruchika Bhat
- & B. Jayaram
-
Article
| Open AccessIn vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα
- Benjamin Xiaoyi Li
- , Xiangrong Dai
- & Heyu Ni
-
Article
| Open AccessEvaluation method for asymmetric uncertainty of quantitative polymerase chain reaction measurements of deoxyribonucleic acids with low copy number
- Unoh Ki
- , Takeru Suzuki
- & Hirotaka Unno
-
Article
| Open AccessSmall molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers
- Martina Meßner
- , Melanie M. Mandl
- & Johanna Pachmayr
-
Article
| Open AccessDevelopment of P301S tau seeded organotypic hippocampal slice cultures to study potential therapeutics
- James M. McCarthy
- , Jasmeet Virdee
- & Hugh N. Nuthall
-
Article
| Open AccessRepurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicase
- Syed Hani Abidi
- , Nahlah Makki Almansour
- & Syed Ali
-
Article
| Open AccessElucidating direct kinase targets of compound Danshen dropping pills employing archived data and prediction models
- Tongxing Wang
- , Lu Liang
- & Yunhui Hu
-
Article
| Open AccessA survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics
- Jessica Knox
- , Nicolas Joly
- & Peter J. Roy