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Nature 452, 543-545 (3 April 2008) | doi:10.1038/452543a; Published online 2 April 2008
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Clinical Gastroenterologists
- University of Maryland
- Baltimore, MD 21201 United States
Assistant Curator
- University of Southampton
- Southampton, UK
RNA interference: Generic block on angiogenesis
Raghu Kalluri1 & Keizo Kanasaki1
Abstract
A virtue of using small interfering RNAs as therapeutics is their exquisite specificity. But when it comes to inhibiting blood-vessel growth, it seems that they can act generically without even entering a cell.
Angiogenesis, the formation of new blood vessels from a pre-existing capillary network, is not always healthy. It accompanies the growth of cancers1, and occurs as the 'choroidal neovascularization' that is associated with the eye disease called age-related macular degeneration2.
- Raghu Kalluri and Keizo Kanasaki are in the Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
Email: rkalluri@bidmc.harvard.edu
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