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Nature 452, 547 (3 April 2008) | doi:10.1038/452547a; Published online 2 April 2008

Molecular cancer diagnostics

Barbara Marte1, Alex Eccleston1 & Deepa Nath1

A myriad of differences in the biological make-up of cancers compared with their healthy-tissue counterparts have been catalogued. Large-scale analyses have detailed the heterogeneity of these changes at the genetic and epigenetic levels, as well as in gene-expression profiles and signal-transduction networks in a wide range of cancers.