Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy
Djamel Lebeche*, Amy J Davidoff and Roger J Hajjar
Correspondence *Cardiovascular Research Center, Mount Sinai School of Medicine, Atran Building AB5-10, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
Email djamel.lebeche@mssm.edu
The existence of diabetic cardiomyopathy has been debated; however, substantial data now demonstrate that diabetes impairs ventricular function independent of other risk factors. Here Lebeche et al. examine the hypothesis that impaired calcium regulation and insulin signaling contribute to the detrimental effect of diabetes on cardiomyocyte function. How these two abnormalities interact to induce cardiac dysfunction is also investigated.
Full text of this article is available with one of the following:
- Personal subscription Purchase your own personal subscription to this journal. Already a subscriber? Please log in for immediate access.
- 7 day single article pass for US$32 In order to purchase this article you must be a registered user. Please register or log in.
- Site licence Learn more about institutional site licences
Current Subscribers
Please log in to access the full text article using the login box at the top of the page.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Calcium and heart failure: the cycle gameNature Medicine News and Views (01 May 2003)
Is calcium the 'cure' for dilated cardiomyopathy?Nature Medicine News and Views (01 Dec 1999)
See all 4 matches for News And ViewsRESEARCH
Mechanical and Metabolic Rescue in a Type II Diabetes Model of Cardiomyopathy by Targeted Gene TransferMolecular Therapy Original Article
See all 27 matches for Research
