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Competing to destroy: a fight between two RNA-degradation systems

Nature Structural & Molecular Biology volume 15, pages 1001–1002 (2008)Cite this article

The Argonaute-1 (Ago1) protein bound to small interfering RNAs (siRNAs) directs heterochromatin formation in fission yeast. A high-throughput sequencing approach reveals that the composition of the Ago1-bound siRNA population is sensitive to the noncanonical poly(A) polymerase Cid14, indicating that the RNA-interference and Cid14-TRAMP RNA-degradation pathways compete for substrates in fission yeast.

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Figure 1: Silencing pathways in fission yeast centromeric heterochromatin.
Figure 2: Competition for substrates by TRAMP and RNAi.

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Authors and Affiliations

  1. Geneviève Thon is in the Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark. gen@bio.ku.dk,

    Geneviève Thon

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Thon, G. Competing to destroy: a fight between two RNA-degradation systems. Nat Struct Mol Biol 15, 1001–1002 (2008). https://doi.org/10.1038/nsmb1008-1001

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