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PORE-ing over ERK substrates

Nature Structural & Molecular Biology volume 16, pages 1004–1005 (2009)Cite this article

A functional proteomics study reveals that nuclear pore proteins are direct substrates for mitogen-activated protein (MAP) kinases, leading to a new mechanism for growth factor control of nuclear transport.

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Figure 1: Experimental strategy for identifying ERK1 and ERK2 substrates.
Figure 2: ERK1 and ERK2 inhibit nuclear transport of importin-β and transportin, by directly phosphorylating the FG repeat nucleoporins Nup50, Nup153 and Nup214.

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  1. Natalie G. Ahn is in the Department of Chemistry & Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado.,

    Natalie G Ahn

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  1. Natalie G Ahn
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Correspondence to Natalie G Ahn.

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Ahn, N. PORE-ing over ERK substrates. Nat Struct Mol Biol 16, 1004–1005 (2009). https://doi.org/10.1038/nsmb1009-1004

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