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Clinical Studies

Effects of a combined exercise and dietary intervention on body composition, physical functioning and fatigue in patients with ovarian cancer: results of the PADOVA trial

British Journal of Cancer (2024)Cite this article

Subjects

Abstract

Background

Guidelines recommend to include exercise and dietary advice in standard care for patients with cancer, based on evidence primarily derived from patients with breast cancer. Its applicability to patients with ovarian cancer is uncertain due to differences in patient characteristics and treatments. The PADOVA trial examined the effectiveness of a combined exercise and dietary intervention on fat-free mass (FFM), physical functioning, and fatigue.

Methods

In total, 81 patients with ovarian cancer were randomised to the exercise and dietary intervention (n = 40) or control (n = 41) group. Measurements were performed before chemotherapy, after chemotherapy, and 12 weeks later. FFM was assessed by bioelectrical impedance analysis, and physical functioning and fatigue were assessed using questionnaires. Intervention effects were assessed on an intention-to-treat basis using linear mixed models.

Results

FFM and physical functioning increased, and fatigue decreased significantly over time in both groups. No significant difference between the groups were found for FFM (β = −0.5 kg; 95% CI = −3.2; 2.1), physical functioning (β = 1.4; 95% CI = −5.4; 8.3) and fatigue (β = 0.7; 95% CI = −1.5; 2.8).

Conclusions

During treatment, both groups improved in FFM, physical functioning, and fatigue. The intervention group, however, did not demonstrate additional benefits compared to the control group. This highlights the need for caution when extrapolating findings from different cancer populations to patients with ovarian cancer.

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Data availability

The datasets used and/or analysed during this study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors acknowledge the Dutch Cancer Society for funding this study, and all study participants.

Funding

The PADOVA study is funded by the Dutch Cancer Society, grant number VU 2015–7950. The Dutch Cancer Society was not involved in the conceptualisation, design, data collection, analysis, decision to publish, nor in preparation of the manuscript.

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Authors and Affiliations

  1. Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands

    Marlou-Floor Kenkhuis, Stephanie Stelten, Yvonne AW. Hartman, Calvin G. Brouwer, Marieke R. ten Tusscher & Laurien M. Buffart

  2. Obstetrics and Gynaecology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

    Luc RCW. van Lonkhuijzen & Gemma G. Kenter

  3. Obstetrics and Gynaecology, Cancer Center Amsterdam, Center for Gynaecologic Oncology Amsterdam (CGOA), Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

    Gemma G. Kenter

  4. Gynaecology, Center for Gynaecologic Oncology Amsterdam (CGOA), The Netherlands Cancer Institute—Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Gemma G. Kenter & Willemien J. van Driel

  5. Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands

    Renate M. Winkels

  6. Department of Obstetrics and Gynaecology, Grow school for oncology and reproduction, Maastricht University, Maastricht, The Netherlands

    Ruud LM. Bekkers

  7. Department of Gynecology, Catharina Hospital, Eindhoven, The Netherlands

    Ruud LM. Bekkers

  8. Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands

    Ruud LM. Bekkers & Nelleke PB. Ottevanger

  9. CoRPS—Center of Research on Psychological and Somatic Disorders, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands

    Meeke Hoedjes

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Contributions

LB, MH, GK and SS designed the study. SS and YH coordinated the trial, collected and assembled the data. MK analysed the data, and LB and MK drafted the manuscript. CB, MtT, LvL, WvD, RB and PO contributed to patient recruitment and measurements. MH and LB assisted with conceptualising the analyses and interpreting the results. All authors critically revised the manuscript and approved the final manuscript.

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Correspondence to Laurien M. Buffart.

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Kenkhuis, MF., Stelten, S., Hartman, Y.A. et al. Effects of a combined exercise and dietary intervention on body composition, physical functioning and fatigue in patients with ovarian cancer: results of the PADOVA trial. Br J Cancer (2024). https://doi.org/10.1038/s41416-024-02694-8

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