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Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities

The Journal of Antibiotics (2024)Cite this article

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Abstract

Three new nonenes, verrucanonenes A‒C (1‒3), were isolated from culture broth of marine-derived fungus Albifimbria verrucaria. These compounds were isolated using silica gel column chromatography, reversed-phase medium pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined using a spectroscopic method. Cytotoxicities of these isolated compounds to A549, DU145, HCT116, and HT1080 cancer cell lines were assessed. Compounds 1‒3 exhibited cytotoxicities to DU145 cancer cell line, with IC50 values of 23.4, 28.6, and 20.1 µM, respectively. Compound 2 decreased H1N1-induced cytopathic effects on MDCK cells in a dose-dependent manner.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2021R1A2C1094267) and the authors thank Ms. Ji-Young Oh, Center for University-wide Research Facilities (CURF) at Jeonbuk National University, for performing NMR measurements.

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Authors and Affiliations

  1. Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan, 54596, Republic of Korea

    Young-Hee Kim, Dae-Cheol Choi, Dae-Won Ki, In-Kyoung Lee & Bong-Sik Yun

  2. Division of Research Management, Department of Bioresource Industrialization, Honam National Institute of Biological Resource, Mokpo, Republic of Korea

    Yeong-Seon Won

  3. Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea

    Yeong-Seon Won & Seung-Jae Lee

  4. Department of Applied Biotechnology, University of Science and Technology (UST), Daejeon, 34113, Republic of Korea

    Seung-Jae Lee

  5. Department of Genetic Resources Research, National Marine Biodiversity Institute of Korea, Seocheon, Republic of Korea

    Ji-Yul Kim

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  1. Young-Hee Kim
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Correspondence to In-Kyoung Lee or Bong-Sik Yun.

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Kim, YH., Choi, DC., Ki, DW. et al. Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities. J Antibiot (2024). https://doi.org/10.1038/s41429-024-00735-1

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  • DOI: https://doi.org/10.1038/s41429-024-00735-1

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