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Custom protein nanoparticles for targeted drug delivery

Nature Structural & Molecular Biology (2024)Cite this article

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Targeted biologics delivery requires programming multicomponent protein nanomaterials to enable selective targeting and response to environment changes in a single unified framework. A novel protein nanoparticle platform has been designed to modulate cell-surface target specificity, cargo packaging, and pH-dependent release of encapsulated cargo, providing exciting possibilities in biologics delivery.

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Fig. 1: Designed plugged antibody nanoparticles can incorporate multiple distinct antibodies and be tuned to disassemble in response to pH changes.

References

  1. Boyken, S. E. et al. De novo design of tunable, pH-driven conformational changes. Science 364, 658–664 (2019). This paper reports the engineering of proteins to respond to changes in pH.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Divine, R. et al. Designed proteins assemble antibodies into modular nanocages. Science 372, eabd9994 (2021). This paper reports the design of antibody-incorporating nanoparticles.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hsia, Y. et al. Design of multi-scale protein complexes by hierarchical building block fusion. Nat. Commun. 12, 2294 (2021). This paper reports a computational helical fusion method.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Sheffler, W. et al. Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock. PLOS Comput. Biol. 19, e1010680 (2023). This paper reports a computational rigid-body docking method.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Yang, E. C. et al. Computational design of non-porous pH-responsive antibody nanoparticles. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-024-01288-5 (2024).

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Custom protein nanoparticles for targeted drug delivery. Nat Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01289-4

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  • DOI: https://doi.org/10.1038/s41594-024-01289-4

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