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Diederichs and colleagues review RNA motifs, focusing on four recent studies identifying nuclear-retention motifs, and discuss the limited specificity of short RNA motifs and the resulting challenge for effective functional prediction.
Nichols and Corces summarize the current knowledge of SMC structure and function and propose a new mechanism for SMC motor activity, which is central to the DNA loop extrusion model of genome organization.
Rittinger and Walden review recent structural and functional insights to contrast and compare RBR E3 ubiquitin ligases and their regulation through autoinhibition, post-translational modifications, multimerization and protein-protein interactions.