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| Open AccessStructural insights into the cross-exon to cross-intron spliceosome switch
Cryo-electron microscopy structures of cross-exon pre-B and B-like complexes contribute new insights into the molecular mechanisms that mediate the switch from a cross-exon to a cross-intron organized spliceosome.
- Zhenwei Zhang
- , Vinay Kumar
- & Reinhard Lührmann
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Article
| Open AccessAcquisition of epithelial plasticity in human chronic liver disease
Single-cell RNA sequencing and 3D imaging have revealed the cellular changes and structural reorganization that occur during the progression of human chronic liver disease and as the liver attempts to regenerate.
- Christopher Gribben
- , Vasileios Galanakis
- & Ludovic Vallier
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Article |
Covalent targeted radioligands potentiate radionuclide therapy
Radiopharmaceuticals engineered with click chemistry to selectively bind to tumour-specific proteins can be used to successfully target tumour cells, boosting the pharmacokinetics of radionuclide therapy and improving tumour regression.
- Xi-Yang Cui
- , Zhu Li
- & Zhibo Liu
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Correspondence |
Trials that infected people with common colds can inform today’s COVID-19 challenge trials
- Jonathan Ewbank
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News & Views |
Save the forest to save the tiger — why vegetation conservation matters
The Royal Botanic Gardens, Kew, emphasizes the importance of conserving wild plant species, plus a wonderstruck sky-watcher spots a brilliant meteor, in the weekly dip into Nature’s archive.
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News |
Lab-grown sperm and eggs: ‘epigenetic’ reset in human cells paves the way
Technique wipes away tags on DNA that must be reprogrammed during development of reproductive cells.
- Heidi Ledford
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Editorial |
A global pandemic treaty is in sight: don’t scupper it
Millions of people died of COVID-19 because the fundamental principle of equity between nations was ignored during the outbreak. That must not be allowed to happen again.
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News |
First ‘bilingual’ brain-reading device decodes Spanish and English words
Artificial-intelligence system allows a man who cannot speak coherently to have a conversation in the language of his choice.
- Amanda Heidt
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Article |
In vitro reconstitution of epigenetic reprogramming in the human germ line
- Yusuke Murase
- , Ryuta Yokogawa
- & Mitinori Saitou
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News |
The origin of the cockroach: how a notorious pest conquered the world
Genomic analysis suggests the common kitchen vermin spread from Europe to the world. But it wasn’t originally found in Europe.
- Bianca Nogrady
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Technology Feature |
DeepLabCut: the motion-tracking tool that went viral
Mackenzie and Alexander Mathis were still early in their careers when their software created a sensation. Now they’re using it to support other young scientists.
- Jyoti Madhusoodanan
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Article |
A deep catalogue of protein-coding variation in 983,578 individuals
- Kathie Y. Sun
- , Xiaodong Bai
- & Suganthi Balasubramanian
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News |
China’s Yangtze fish-rescue plan is a failure, study says
Researchers have debated the best management plan for highly endangered fish species since the 1980s.
- Xiaoying You
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News |
Pig-organ transplants: what three human recipients have taught scientists
As researchers mark the loss of the first living recipient of a pig kidney, they share what they’ve learnt about xenotransplantation.
- Max Kozlov
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News |
Could bird flu in cows lead to a human outbreak? Slow response worries scientists
The H5N1 virus is a long way from becoming adapted to humans, but limited testing and tracking mean we could miss danger signs.
- Smriti Mallapaty
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Obituary |
Daniel Dennett obituary: ‘New atheism’ philosopher who sparked debate on consciousness
Cognitive scientist who boldly explored free will, the human mind and AI, and rejected the existence of God.
- Liad Mudrik
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News |
Gut microbes linked to fatty diet drive tumour growth
Scientists know there is a link between obesity and some cancers. A study in mice and people suggests why that might be.
- Gillian Dohrn
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News |
US halts funding to controversial virus-hunting group: what researchers think
Some scientists think the decision regarding EcoHealth Alliance is fair; others say it might negatively affect virus surveillance.
- Mariana Lenharo
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Article |
Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines
- Chieh-Yu Liang
- , Saravanan Raju
- & Michael S. Diamond
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News Feature |
How to kill the ‘zombie’ cells that make you age
Researchers are using new molecules, engineered immune cells and gene therapy to kill senescent cells and treat age-related diseases.
- Carissa Wong
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News & Views |
Dual-action obesity drug rewires brain circuits for appetite
A two-in-one drug that modulates neural pathways involved in appetite and reward might prove to be more effective and longer lasting than current weight-loss drugs on the market.
- Tyler M. Cook
- & Darleen Sandoval
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News & Views |
Parental-care puzzle in mice solved by thinking outside the brain
Both parents of oldfield mice care for offspring, whereas in deer mice, mothers usually care for pups. The discovery of a type of adrenal-gland cell that is present in oldfield mice but not in deer mice helps to explain the difference.
- Jessica Tollkuhn
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Nature Podcast |
Lizard-inspired building design could save lives
How knocking down a building helped researchers design a safer structure, and a sustainable 3D printing resin made from a bodybuilding supplement.
- Benjamin Thompson
- & Elizabeth Gibney
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Editorial |
Forestry social science is failing the needs of the people who need it most
Rich nations’ fixation on forests as climate offsets has resulted in the needs of those who live in or make a living from these resources being ignored. A broader view and more collaboration between disciplines is required.
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Article |
Evolution of a novel adrenal cell type that promotes parental care
The adrenal gland of the oldfield mouse (Peromyscus polionotus) has a recently evolved cell type that promotes monogamous-typical parenting behaviour and is not present in closely related species.
- Natalie Niepoth
- , Jennifer R. Merritt
- & Andres Bendesky
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Article
| Open AccessThe rise of baobab trees in Madagascar
We carried out genomic and ecological analyses of all eight extant baobab species, providing insights into their evolutionary history and recommendations for conservation efforts.
- Jun-Nan Wan
- , Sheng-Wei Wang
- & Qing-Feng Wang
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Article |
Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice
The ubiquitin E3 ligase OsCIE1 acts as a brake to inhibit OsCERK1 during homeostasis; this brake is released after chitin stimulation.
- Gang Wang
- , Xi Chen
- & Ertao Wang
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Review Article |
Decoding the interplay between genetic and non-genetic drivers of metastasis
This Review discusses the importance of genetic and non-genetic reprogramming events during the metastatic cascade.
- Panagiotis Karras
- , James R. M. Black
- & Jean-Christophe Marine
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Article
| Open AccessThe temperature sensor TWA1 is required for thermotolerance in Arabidopsis
TWA1 is a temperature-sensing transcriptional co-regulator that is needed for basal and acquired thermotolerance in Arabidopsis thaliana.
- Lisa Bohn
- , Jin Huang
- & Erwin Grill
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News |
Experimental obesity drug packs double punch to reduce weight
Test of weight-loss candidate in mice shows that there is still room for improvement in a burgeoning field.
- Asher Mullard
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Article
| Open AccessTemporal multiplexing of perception and memory codes in IT cortex
We examined how familiar faces are encoded in inferotemporal, perirhinal and temporal pole face patches, and found that relative response magnitude to familiar versus unfamiliar faces was not a stable indicator of familiarity in any patch.
- Liang She
- , Marcus K. Benna
- & Doris Y. Tsao
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Article
| Open AccessPhysiological temperature drives TRPM4 ligand recognition and gating
A temperature-dependent Ca2+-binding site in the intracellular domain of TRPM4 is essential for TRPM4 function in physiological contexts.
- Jinhong Hu
- , Sung Jin Park
- & Wei Lü
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Article
| Open AccessEngineered CD47 protects T cells for enhanced antitumour immunity
Combination of TCR or CAR T cells expressing the engineered CD47 variant 47E with anti-CD47 antibody therapy results in synergistic antitumour efficacy due to T cell resistance to clearance by macrophages, while maintaining macrophage recruitment into the tumour microenvironment.
- Sean A. Yamada-Hunter
- , Johanna Theruvath
- & Crystal L. Mackall
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Article
| Open AccessVolatile working memory representations crystallize with practice
Delay- and choice-related activities that are essential for working-memory performance drift during learning and stabilize only after several days of expert performance.
- Arash Bellafard
- , Ghazal Namvar
- & Peyman Golshani
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Article |
Dimerization and antidepressant recognition at noradrenaline transporter
Cryo-electron microscopy structures of the noradrenaline transporter in the apo state, bound to noradrenaline and bound to various antidepressants shed light on the substrate transport, molecular recognition and dimeric architecture of this protein.
- Heng Zhang
- , Yu-Ling Yin
- & Yi Jiang
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Article
| Open AccessGLP-1-directed NMDA receptor antagonism for obesity treatment
Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.
- Jonas Petersen
- , Mette Q. Ludwig
- & Christoffer Clemmensen
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News & Views |
Balls of lightning and flames from the sky: can science explain?
A book cataloguing mysterious events challenges scientists to provide some answers, and Charles Darwin continues his investigations of crimes against primroses, in the weekly dip into Nature’s archive.
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News & Views |
The phenomenon of genomic imprinting was discovered 40 years ago
Some genes carry an ‘imprint’ on either the maternal or the paternal copy, which determines whether or not that copy is expressed. This 1984 discovery changed how scientists think about gene regulation and inheritance.
- Anne C. Ferguson-Smith
- & Marisa S. Bartolomei
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News Feature |
How does ChatGPT ‘think’? Psychology and neuroscience crack open AI large language models
Researchers are striving to reverse-engineer artificial intelligence and scan the ‘brains’ of LLMs to see what they are doing, how and why.
- Matthew Hutson
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Book Review |
How men evolved to care for babies — before society got in the way
An exploration of the evolution of male nurturing shows why, unlike fathers among other great apes, human dads are biologically wired to be hands-on parents.
- Kermyt G. Anderson
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Research Briefing |
Mega study charts how genetic variants affect metabolism
A genome-wide association study of metabolic biomarkers in 136,000 participants discovered more than 400 independent genomic regions affecting metabolism. The study also highlighted the importance of participant characteristics, such as fasting status, that can substantially affect the genetic associations.
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World View |
Why mathematics is set to be revolutionized by AI
Cheap data and the absence of coincidences make maths an ideal testing ground for AI-assisted discovery — but only humans will be able to tell good conjectures from bad ones.
- Thomas Fink
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Article |
Plasmid targeting and destruction by the DdmDE bacterial defence system
- Jack P. K. Bravo
- , Delisa A. Ramos
- & David W. Taylor
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Where I Work |
Why my heart beats for Nigeria’s endangered bats
Iroro Tanshi works to better understand a number of threatened species.
- Linda Nordling
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News |
Human embryos embrace asymmetry to form the body
The cells generated by the very first division of the fertilized egg make a lopsided contribution to the body’s organs and tissues.
- Sara Reardon
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News |
World’s brightest X-rays: China first in Asia to build next-generation synchrotron
The US$665-million High Energy Photon Source (HEPS) outside Beijing puts China among only a handful of countries that have fourth-generation synchrotron light sources.
- Gemma Conroy
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News |
Brain-reading device is best yet at decoding ‘internal speech’
Technology that enables researchers to interpret brain signals could one day allow people to talk using only their thoughts.
- Miryam Naddaf
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News |
Is the Internet bad for you? Huge study reveals surprise effect on well-being
A survey of more than 2.4 million people finds that being online can have a positive effect on welfare.
- Carissa Wong
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Research Highlight |
These parrots go on killing sprees over real-estate shortages
Scientists recorded green-rumped parrotlets pecking others’ chicks to death, probably to claim the nest space.
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