Cellular neuroscience articles within Nature

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  • Article
    | Open Access

    The authors identify naturally occurring senescent glia in aged Drosophila brains and decipher their origin and influence, determining that they can appear in response to neuronal mitochondrial dysfunction and that they promote lipid accumulation, indicating that these cells link key ageing phenomena.

    • China N. Byrns
    • , Alexandra E. Perlegos
    •  & Nancy M. Bonini

  • Article
    | Open Access

    Experiments using fentanyl treatment of mice show that µ-opioid receptors mediate positive reinforcement in the ventral tegmental area and negative reinforcement in central amygdala, thereby identifying the circuits that lead to opioid addiction.

    • Fabrice Chaudun
    • , Laurena Python
    •  & Christian Lüscher

  • Article
    | Open Access

    Signalling by the developmental morphogen BMP2 through the transcription factor SMAD1 has a key role in controlling the glutamatergic innervation of parvalbumin-expressing interneurons and maintaining the balance between excitation and inhibition in the mammalian cortex.

    • Zeynep Okur
    • , Nadia Schlauri
    •  & Peter Scheiffele

  • Article
    | Open Access

    Learning results in persistent double-stranded DNA breaks, nuclear rupture and release of DNA fragments and histones within hippocampal CA1 neurons that, following TLR9-mediated DNA damage repair, results in their recruitment to memory circuits.

    • Vladimir Jovasevic
    • , Elizabeth M. Wood
    •  & Jelena Radulovic

  • Article
    | Open Access

    In response to acute thermal challenge, thermosensing glutamatergic neurons of the parabrachial nucleus in mouse brain activate tanycytes, which reduce the excitability of Flt1-expressing dopamine and agouti-related peptide-containing neurons, thus suppressing appetite.

    • Marco Benevento
    • , Alán Alpár
    •  & Tibor Harkany

  • Article
    | Open Access

    Audio and visual stimulation at 40 Hz promote cerebrospinal and interstitial fluid flux in mouse brain and result in amyloid clearance via the glymphatic system in a mouse model of Alzheimer’s disease.

    • Mitchell H. Murdock
    • , Cheng-Yi Yang
    •  & Li-Huei Tsai

  • Article
    | Open Access

    In mice, a population of astrocytes in the central striatum, characterized by expression of μ-crystallin, has a role in perseveration phenotypes that are often associated with human neuropsychiatric disorders.

    • Matthias Ollivier
    • , Joselyn S. Soto
    •  & Baljit S. Khakh

  • Article
    | Open Access

    A stream of young neurons migrating into the entorhinal cortex (EC) continues postnatally in humans, but not in macaques; these young neurons, which belong to a unique class of local circuit cells, continue to be recruited in the EC during infancy and early childhood.

    • Marcos Assis Nascimento
    • , Sean Biagiotti
    •  & Shawn F. Sorrells

  • Article
    | Open Access

     A transcriptomic cell-type atlas of the whole adult mouse brain with ~5,300 clusters built from single-cell and spatial transcriptomic datasets with more than eight million cells reveals remarkable cell type diversity across the brain and unique cell type characteristics of different brain regions. 

    • Zizhen Yao
    • , Cindy T. J. van Velthoven
    •  & Hongkui Zeng

  • Article
    | Open Access

    To construct a comprehensive atlas of cell types in each brain structure, we paired high-throughput single-nucleus RNA sequencing with Slide-seq, a recently developed spatial transcriptomics method with near-cellular resolution, across the entire mouse brain.

    • Jonah Langlieb
    • , Nina S. Sachdev
    •  & Evan Z. Macosko

  • Article |

    The authors identify a molecular switch that regulates the balance between neurotoxic and neuroprotective astrocyte populations, with potential application in the treatment of glaucoma and other optic neuropathies.

    • Evan G. Cameron
    • , Michael Nahmou
    •  & Jeffrey L. Goldberg

  • Article
    | Open Access

    Calcium-permeable GluA1 AMPA glutamate receptors are structurally and functionally distinct from the prototypical GluA2-containing AMPA receptors, impacting their role in signal transmission, synaptic plasticity and learning.

    • Danyang Zhang
    • , Josip Ivica
    •  & Ingo H. Greger

  • Article
    | Open Access

    Several independent lines of evidence demonstrated long-term potentiation induction by a structural function of calmodulin-dependent protein kinase II rather than by its enzymatic activity.

    • Jonathan E. Tullis
    • , Matthew E. Larsen
    •  & K. Ulrich Bayer

  • Article
    | Open Access

    The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.

    • Di Zhang
    • , Yanxiang Deng
    •  & Rong Fan

  • Article
    | Open Access

    Analysis of data collected from mice learning a trace conditioning paradigm shows that phasic dopamine activity in the brain can regulate direct learning of behavioural policies, and dopamine sets an adaptive learning rate rather than an error-like teaching signal.

    • Luke T. Coddington
    • , Sarah E. Lindo
    •  & Joshua T. Dudman

  • Article |

    Synaptotagmin-3 is identified as the presynaptic high-affinity calcium sensor to rapidly replenish synaptic vesicles to maintain steady synaptic transmission.

    • Dennis J. Weingarten
    • , Amita Shrestha
    •  & Skyler L. Jackman

  • Article
    | Open Access

    Endocytosis and degradation of plasma membrane proteins in the axon initial segment, together with the diffusion-barrier mechanism, maintain a polarized distribution of plasma membrane proteins in Caenorhabditis elegans, mouse, rat and human neurons.

    • Kelsie Eichel
    • , Takeshi Uenaka
    •  & Kang Shen

  • Article |

    Experiments measuring light-evoked responses in postmortem mouse and human retinas are used to quantify decay of photoreceptors following death and optimise conditions for reviving trans-synaptic transmission.

    • Fatima Abbas
    • , Silke Becker
    •  & Frans Vinberg

  • Article |

    A chromatin accessibility atlas of 240,919 cells in the adult and developing Drosophila brain reveals 95,000 enhancers, which are integrated in cell-type specific enhancer gene regulatory networks and decoded into combinations of functional transcription factor binding sites using deep learning.

    • Jasper Janssens
    • , Sara Aibar
    •  & Stein Aerts

  • Article
    | Open Access

    Sparse labelling and whole-brain imaging are used to reconstruct and classify brain-wide complete morphologies of 1,741 individual neurons in the mouse brain, revealing a dependence on both brain region and transcriptomic profile.

    • Hanchuan Peng
    • , Peng Xie
    •  & Hongkui Zeng

  • Article
    | Open Access

    An examination of motor cortex in humans, marmosets and mice reveals a generally conserved cellular makeup that is likely to extend to many mammalian species, but also differences in gene expression, DNA methylation and chromatin state that lead to species-dependent specializations.

    • Trygve E. Bakken
    • , Nikolas L. Jorstad
    •  & Ed S. Lein

  • Article
    | Open Access

    A comprehensive survey of the epigenome from 45 regions of the mouse cortex, hippocampus, striatum, pallidum and olfactory areas using single-nucleus DNA methylation sequencing enables identification of 161 cell clusters with distinct locations and projection targets and provides insights into the regulatory landscape underlying neuronal diversity and spatial regulation.

    • Hanqing Liu
    • , Jingtian Zhou
    •  & Joseph R. Ecker

  • Article
    | Open Access

    Combined patch clamp recording, biocytin staining and single-cell RNA-sequencing of human neurocortical neurons shows an expansion of glutamatergic neuron types relative to mouse that characterizes the greater complexity of the human neocortex.

    • Jim Berg
    • , Staci A. Sorensen
    •  & Ed S. Lein

  • Article
    | Open Access

    The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • , Hong-Wei Dong
    •  & Susan Sunkin

  • Article |

    Single-nucleus transcriptomes of frontal cortex and choroid plexus samples from patients with COVID-19 reveal pathological cell states that are similar to those associated with human neurodegenerative diseases and chronic brain disorders.

    • Andrew C. Yang
    • , Fabian Kern
    •  & Tony Wyss-Coray

  • Article |

    A cell-surface fragment complementation strategy is used to identify the proteome at the junction of astrocytes and synapses in vivo, and shows that NRCAM expressed in astrocytes has a key role in regulating inhibitory synapse function.

    • Tetsuya Takano
    • , John T. Wallace
    •  & Scott H. Soderling

  • Article |

    In the thalamic reticular nucleus there are two neuron types that are segregated into central and edge zones and receive inputs from different thalamocortical nuclei, creating subcircuits with distinct dynamics.

    • Rosa I. Martinez-Garcia
    • , Bettina Voelcker
    •  & Scott J. Cruikshank

  • Article |

    Cryo-electron microscopy structures of heterodimeric and homodimeric full-length GABAB receptors, combined with cellular signalling assays, shed light on the mechanisms that underpin signal transduction mediated by these receptors.

    • Makaía M. Papasergi-Scott
    • , Michael J. Robertson
    •  & Georgios Skiniotis

  • Article |

    Acetate that is produced from the breakdown of alcohol contributes to histone acetylation in the brain, indicating that there is a direct link between alcohol metabolism and gene expression.

    • P. Mews
    • , G. Egervari
    •  & S. L. Berger

  • Article |

    RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.

    • Rebecca D. Hodge
    • , Trygve E. Bakken
    •  & Ed S. Lein

  • Letter |

    Neural blastocyst complementation creates a vacant forebrain niche in host embryos that can be populated by donor embryonic stem cell-derived dorsal telencephalic progenitors, resulting in a mouse brain organogenesis model.

    • Amelia N. Chang
    • , Zhuoyi Liang
    •  & Frederick W. Alt

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