Article
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Open Access
Featured
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Article |
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
- Bernard Thienpont
- , Jessica Steinbacher
- & Diether Lambrechts
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Review Article |
Metabolism of stromal and immune cells in health and disease
This Review discusses stromal and immune cell metabolism and its implications for health and disease.
- Bart Ghesquière
- , Brian W. Wong
- & Peter Carmeliet
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News & Views |
Limitations of therapies exposed
Certain drugs that are used to treat cancer affect blood-vessel formation in tumours. But it seems that these antiangiogenic drugs can reduce the efficiency of other anticancer agents and increase the tumours' aggressiveness.
- Oriol Casanovas
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Letter |
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
- Andrea Facciabene
- , Xiaohui Peng
- & George Coukos
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News |
Tumours grow their own blood vessels
Finding explains failure of drugs that target host vasculature.
- Alla Katsnelson
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Letter |
Glioblastoma stem-like cells give rise to tumour endothelium
This is one of two papers showing that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells. The tumour-derived endothelial cells originate in putative glioblastoma-initiating cells and are functionally important for tumorigenesis.
- Rong Wang
- , Kalyani Chadalavada
- & Viviane Tabar
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Letter |
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
This is one of two papers showing that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells. The tumour-derived endothelial cells originate in putative glioblastoma-initiating cells and are functionally important for tumorigenesis.
- Lucia Ricci-Vitiani
- , Roberto Pallini
- & Ruggero De Maria
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Research Highlights |
Cancer biology: Blood vessel regulator
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Letter |
Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome
Down's syndrome is caused by trisomy of chromosome 21, and it is known that the growth of certain tumours is reduced in this genetic disorder. Using a mouse model of Down's syndrome, several individual genes on chromosome 21 are now being proposed to mediate the effect on tumour growth and angiogenesis.
- Louise E. Reynolds
- , Alan R. Watson
- & Kairbaan M. Hodivala-Dilke