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Reply to “Synaptic scaling in vitro and in vivo”

Nature Neuroscience volume 4, pages 854–855 (2001)Cite this article

Reply

We welcome the intent of the letter by London and Segev to reaffirm the well-known fact that network activity can change the cable properties of neurons11 (also see ref. 13 for further references). We show the same effect in Figure 4d (ref. 1), and one of us has recently published papers specifically on this issue12,13. We do not agree, however, with the supposition that computer simulations using unrealistic model neurons can tell us much of substance about synaptic integration under in vivo conditions. If computer models are to provide enhanced understanding of neuronal integration, they need to reflect as closely as possible the conditions they wish to simulate.

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Authors and Affiliations

  1. Louisiana State University Medical Center, 2020 Gravier St., New Orleans, 70112, Louisiana, USA

    Jeffrey C. Magee

  2. Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Place, Houston, 77050, Texas, USA

    Erik P. Cook

Authors
  1. Jeffrey C. Magee
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  2. Erik P. Cook
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Magee, J., Cook, E. Reply to “Synaptic scaling in vitro and in vivo”. Nat Neurosci 4, 854–855 (2001). https://doi.org/10.1038/nn0901-854

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