Abstract
This special issue of Nature Reviews Immunology focuses on the types of lymphocyte that blur the traditional boundaries between the innate and adaptive immune systems. The development and functional properties of 'innate-like' B and T cells and natural killer (NK) cells are reviewed and the emerging understanding of newly discovered innate lymphoid cells (ILCs) is considered.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
Nature Communications Open Access 29 July 2019
-
Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis
Scientific Reports Open Access 13 February 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Brennan, P. J., Brigl, M. & Brenner, M. B. Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nature Rev. Immunol. 13, 101–117 (2013).
Gold, M. C. & Lewinsohn, D. M. Co-dependents: MR1-restricted MAIT cells and their antimicrobial function. Nature Rev. Microbiol. 11, 14–19 (2013).
Vantourout, P. & Hayday, A. Six-of-the-best: unique contributions of γδ T cells to immunology. Nature Rev. Immunol. 13, 88–100 (2013).
Cerutti, A., Cols, M. & Puga, I. Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes. Nature Rev. Immunol. 13, 118–132 (2013).
Vivier, E. et al. Innate or adaptive immunity? The example of natural killer cells. Science 331, 44–49 (2011).
Bezman, N. A. et al. Molecular definition of the identity and activation of natural killer cells. Nature Immunol. 13, 1000–1009 (2012).
Parham, P. & Moffett, A. Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution. Nature Rev. Immunol. 13, 133–144 (2013).
Walker, J. A., Barlow, J. L. & McKenzie, A. N. J. Innate lymphoid cells — how did we miss them? Nature Rev. Immunol. 13, 75–87 (2013).
Spits, H. & Cupedo, T. Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu. Rev. Immunol. 30, 647–675 (2012).
Spits, H. et al. Innate lymphoid cells — a proposal for uniform nomenclature. Nature Rev. Immunol. 13, 145–149 (2013).
Acknowledgements
L.L.L. is an American Cancer Society Professor and is supported by US National Institutes of Health grants AI066897, AI068129 and CA095137.
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Related links
Rights and permissions
About this article
Cite this article
Lanier, L. Shades of grey — the blurring view of innate and adaptive immunity. Nat Rev Immunol 13, 73–74 (2013). https://doi.org/10.1038/nri3389
Published:
Issue Date:
DOI: https://doi.org/10.1038/nri3389
This article is cited by
-
The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo
Cellular & Molecular Immunology (2021)
-
Drivers of Inflammation in Psoriatic Arthritis: the Old and the New
Current Rheumatology Reports (2021)
-
Innate-like Lymphocytes and Innate Lymphoid Cells in Asthma
Clinical Reviews in Allergy & Immunology (2020)
-
Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE
Cellular & Molecular Immunology (2019)
-
Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
Nature Communications (2019)