The exact relationship between 3D chromatin interactions and enhancer function is unclear. By probing three-dimensional enhancer interactions in developing embryos, two studies now show nuanced dynamics in tissue-specific contexts and reveal how moderately increased enhancer–promoter interactions coincide with functionality.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pollex, T. et al. Nat. Genet. https://doi.org/10.1038/s41588-024-01678-x (2024).
Chen, Z. et al. Nat. Genet. https://doi.org/10.1038/s41588-024-01681-2 (2024).
Ghavi-Helm, Y. et al. Nature 512, 96–100 (2014).
Andrey, G. et al. Genome Res. 27, 223–233 (2017).
Beagan, J. A. et al. Nat. Neurosci. 23, 707–717 (2020).
Oudelaar, A. M. & Higgs, D. R. Nat. Rev. Genet. 22, 154–168 (2021).
Bonev, B. et al. Cell 171, 557–572.e24 (2017).
Siersbæk, R. et al. Mol. Cell 66, 420–435.e5 (2017).
Murphy, D. et al. Nat. Struct. Mol. Biol. 31, 125–140 (2024).
Benabdallah, N. S. et al. Mol. Cell 76, 473–484.e7 (2019).
Alexander, J. M. et al. Elife 8, (2019).
Monahan, K., Horta, A. & Lomvardas, S. Nature 565, 448–453 (2019).
Visel, A., Minovitsky, S., Dubchak, I. & Pennacchio, L. A. Nucleic Acids Res. 35, D88–D92 (2007).
Zuin, J. et al. Nature 604, 571–577 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Ibrahim, D.M. Enhancer contacts during embryonic development show diverse interaction modes and modest yet significant increases upon gene activation. Nat Genet 56, 558–560 (2024). https://doi.org/10.1038/s41588-024-01700-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-024-01700-2