Cohousing pet-store mice with laboratory mice leads to the natural transfer of microbes and subsequent inflammation in laboratory mice. Lung group 2 innate lymphoid cells — rapid responders to airway allergens — are transiently inhibited by inflammatory signals, but their activity recovers once the active infection subsides.
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References
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This is a summary of: Block, K. E. et al. Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens. Nat. Immunol. https://doi.org/10.1038/10.1038/s41590-022-01350-8 (2022).
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Natural mouse microbes transiently block innate responses to allergens. Nat Immunol 23, 1669–1670 (2022). https://doi.org/10.1038/s41590-022-01352-6
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DOI: https://doi.org/10.1038/s41590-022-01352-6
