Nature Immunology - Current issue : December 2008 - Vol 9 No 12
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Article of the month
Dicer proteins direct RNA-interference activities. Imler and colleagues show that Dicer-2 induces a Vago-dependent antiviral response in flies and that Dicer proteins are related to RIG-I viral sensors.
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News & Views by Takeuchi & AkiraAdvance online publication
Degrees of exhaustion
Article by BlackburnChronic infection can lead to T cell exhaustion. Wherry and colleagues demonstrate that a hierarchy of inhibitory receptors coregulates CD8+ T cell exhaustion during chronic viral infection.
Current issue
Nedd4 versus Itch
Article by YangItch and Nedd4 E3 ubiquitin ligases target similar proteins in vitro. Oliver and colleagues find that unlike hyper-responsive Itch-mutant T cells, Nedd4-deficient T cells are hypo-responsive and contain excess Cbl-b.
Current issue
Neuroendocrine immune inputs
Article by KawliIn a variety of organisms, signals from the nervous system influence adaptive immunity. Tan and Kawli now show the importance of neuroendocrine inputs in innate immunity of C. elegans against bacterial pathogens.
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News & Views by Kao, Los & AroianCurrent issue
TGF-β promotes the differentiation of TH-17 and regulatory T cells. The Stockinger and Kuchroo laboratories show that TGF-β also directs differentiation of a unique interleukin 9–producing T cell subset.
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News & Views by Tato & CuaCurrent issue
Multifaceted Foxo1
Article by DenglerFoxo transcription factors are linked to complex regulatory circuits governed by the availability of phosphatidylinositol-3,4,5-trisphosphate. Rickert and colleagues show that Foxo1 has nonredundant functions at many stages of B cell development.