With the genetics of a laboratory strain but a more diverse microbiome, ‘wildling’ mice could be a novel complement to commonly used specific pathogen-free animals in preclinical studies.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes
npj Biofilms and Microbiomes Open Access 22 January 2021
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wong, C. H., Siah, K. W. & Lo, A. W. Biostatistics 20, 273–286 (2019).
Knight, R. et al. Annu Rev Genomics Hum. Genet 18, 65–86 (2017).
Belkaid, Y. & Hand, T. W. Cell 157, 121–141 (2014).
Rosshart, S. P. et al. Science 365, eaa24361 (2019).
Suntharalingam, G. et al. N. Engl. J. Med. 355, 1018–1028 (2006).
Tacke, M., Hanke, G., Hanke, T. & Hunig, T. Eur. J. Immunol 27, 239–247 (1997).
Beutler, B., Milsark, I. W. & Cerami, A. C. Science 229, 869–871 (1985).
Fisher, C. J. Jr. et al. N. Engl. J. Med. 334, 1697–1702 (1996).
Huggins, M. A. et al. Cell Rep. 28, 1729–1743 (2019).
Fink, M. P. Virulence 5, 143–153 (2014).
Beura, L. K. et al. Nature 532, 512–516 (2016).
Huggins, M. A., Jameson, S. C. & Hamilton, S. E. J. Leukoc. Biol. 105, 73–79 (2019).
Masopust, D., Sivula, C. P. & Jameson, S. C. J. Immunol. 199, 383–388 (2017).
Reese, T. A. et al. Cell Host Microbe 19, 713–719 (2016).
Rosshart, S. P. et al. Cell 171, 1015–1028 e1013 (2017).
Blekhman, R. et al. Genome Biol 16, 191 (2015).
Goodrich, J. K. et al. Cell 159, 789–799 (2014).
Korach-Rechtman, H. et al. App. Environ Microbiol (2019).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Hamilton, S.E., Griffith, T.S. A wild microbiome improves mouse modeling of the human immune response. Lab Anim 48, 337–338 (2019). https://doi.org/10.1038/s41684-019-0421-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41684-019-0421-8
This article is cited by
-
Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes
npj Biofilms and Microbiomes (2021)