Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Enzymes

Taking a walk to find new mucinases

Gut microbes have enzymes that break down the heavily glycosylated mucin protein of host animals, but known enzymes recognize only one glycan chain. Now, bioinformatic exploration has uncovered a family of mucinases that targets dense sugar residues.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: A mucinase specific for dense glycans.

References

  1. Hansson, G. C. Annu. Rev. Biochem. 89, 769–793 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Shon, D. J., Kuo, A., Ferracane, M. J. & Malaker, S. A. Biochem. J. 478, 1585–1603 (2021).

    Article  CAS  PubMed  Google Scholar 

  3. Narimatsu, Y. et al. Nat. Catal. https://doi.org/10.1038/s41929-024-01116-5 (2024).

  4. Luis, A. S. & Hansson, G. C. Cell Host Microbe 31, 1087–1100 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Perdam, K. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01840-6 (2023).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shinya Fushinobu.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fushinobu, S. Taking a walk to find new mucinases. Nat Catal 7, 345–346 (2024). https://doi.org/10.1038/s41929-024-01145-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41929-024-01145-0

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology