Progress in the field of photocatalytic CO₂ reduction has been constrained by a lack of comparability between studies. This Perspective provides recommendations for best practices in the undertaking and reporting of experimental data in this promising research area.

The valorization of methane into oxygenated products has long intrigued the catalysis community, however, progress in the field is disparate and practical implementation remains elusive. This Review discusses recent advances in the area using performance indicators that reveal the gaps between academic investigations and industrial methane utilization and highlight possibilities for further developments.

Understanding the structure–performance relationships of heterogeneous catalysts is of fundamental importance for their deployment in industry. However, gaps exist between the conditions and catalytic materials commonly employed in laboratory studies and those encountered in practical reactors. This Perspective highlights the importance of recognizing such gaps, with the goal to inform the planning of academic research and maximize its impact.

Thanks to a unique set of properties, liquid metal catalysts provide advantages compared to traditional solid systems, yet their potential in heterogeneous catalysis has not been fully explored. This Perspective identifies some of the key advances in the field of liquid metal catalysis, discussing areas where progress is expected through further fundamental understanding as well as reactor engineering.

Olefin hydroformylation is traditionally performed with homogeneous catalysts. Here the authors introduce a heterogeneous system based on zeolite-confined Rh clusters that is characterized by high efficiency for the hydroformylation of C₆–C₁₂ terminal olefins into linear aldehydes with high selectivity.

Photoredox-catalysed coupling of electron-rich aryl electrophiles based on simple nickel salts usually suffers from a slow oxidative addition. Now, it is shown that thianthrenation leads to more favourable redox properties of the substrates, alleviating this problem in carbon–heteroatom bond-forming reactions.

Direct stereoselective amination of tertiary C–H bonds without the assistance of directing groups is a challenging task in synthetic organic chemistry. Now a nitrene transferase is engineered to aminate tertiary C–H bonds with high enantioselectivity, providing direct access to valuable chiral α-tertiary primary amines.

Asymmetric versions of radical-mediated alkene difunctionalizations featuring hydrocarbon precursors are currently elusive. Here the authors report an asymmetric vicinal alkene dicarbofunctionalization based on the activation of C(sp³)–H bonds through the combination of photocatalysed hydrogen atom transfer and nickel catalysis.

Aminated heteroaromatics are usually synthesized from heteroaromatic substrates. Now, a general photochemical approach that exploits non-aromatic N-heterocyclic ketones as starting materials for the coupling with amines under desaturative catalysis is reported as an alternative.

Synthetic methylotrophic organisms provide potential for valorization of greenhouse gas-derived methanol. Here an Escherichia coli strain is generated that reaches a similar growth rate on methanol to many natural methylotrophs and is capable of producing chemicals from this carbon source.