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Transplantation for non-resectable colorectal liver metastasis (CRLM) has become accepted for a few, select patients following stringent criteria. With improved understanding of the selective indications, enhanced curation of the donor pool, and by further insight into cancer biology, novel avenues for research may be developed and eventually benefit more patients with non-resectable CRLM.
Work is ongoing to recover UK clinical research capacity and capabililty post COVID-19 pandemic (https://sites.google.com/nihr.ac.uk/thefutureofukclinicalresearch/home), but many of the barriers investigators faced pre-pandemic persist. Taking a more patient-centred approach to reform may help apply lessons learned during the pandemic and facilitate ‘building back better’.
Metastatic uveal melanoma continues to have a poor prognosis with distinct pathophysiology from cutaneous melanoma and limited effective treatment options. Targeted therapy with darovasertib towards protein kinase C is well tolerated with signals of early efficacy, warranting further exploration and combination strategies.
In an attempt to overcome resistance to immune checkpoint inhibitors (ICI), an ever-increasing number of trials are exploring combination treatment approaches. Outcomes of a novel ICI doublet presented by Desai and colleagues are discussed along with emerging novel strategies and a view to future ongoing rational trial design maximising patient benefit.
Even though the literature shows limited data regarding the epidemiological studies on dietary fibres in malignancies reduction, these nutritional components proved their efficacy in modulating general health status, reducing abdominal disease-associated symptoms, diminishing the inflammation connected with cancerous pathologies, and in health recovery after pelvic cancer radiotherapy.