Nobel Prize in Physiology or Medicine 2019
This collection of research, review and comment from Nature Research celebrates the 2019 Nobel Prize in Physiology or Medicine awarded to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability”. The ability of organisms to respond to changes in oxygen availability is of fundamental importance to life on earth. Work by the prize-winning scientists has shown that in animal cells, oxygen availability affects gene expression through oxygen-sensitive post-translational modification and the subsequent proteasomal degradation of Hypoxia Inducible Factors. This research laid the foundation for understanding the mechanistic basis for the cellular response to hypoxia and paved the way for the therapeutic targeting of the response pathway to treat conditions including cancer and anaemia.
All research papers under ‘From the winners’ are free to access until April 2020.
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This Collection is editorially independent, produced with financial support from a third party. About this content.
Selected content is made freely available for 6 months (until April 2020), thanks to the financial support of GlaxoSmithKline.
GSK – one of the world’s leading research-based pharmaceutical and healthcare companies – is committed to improving the quality of human life by enabling people to do more, feel better and live longer. For further information please visit www.gsk.com
Produced with grant support from Merck & Co., Inc. in Kenilworth, New Jersey.
Produced with support from Akebia Therapeutics.
