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In this Collection, we highlight recent research papers, reviews and commentaries from npj Digital Medicine and npj Schizophrenia that illustrate new developments in digital technology related to mental health. The papers included look at the effect of digital technology on health and well-being, and how the development of new technology could be used to better diagnose and treat mental health conditions. This is an area of growing of clinical interest, as well as an exciting field in basic and translational research.