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Elevated serum uric acid levels before 20 weeks of gestation are associated with the development of preeclampsia, especially in the early 8–12 weeks of gestation, and the effect attenuates with increasing gestational weeks, which suggest that elevated uric acid in early pregnancy may be a causative factor in preeclampsia.
A mechanistic model on the epigenetics of exercise during pregnancy. Maternal exercise during pregnancy triggers hypermethylation and transcriptional suppression of the Agtr1a gene via increased DNMT1 and DNMT3B expression in MAs of SHR offspring. Downregulation of AT1R expression reduces the contribution of Ang II to vascular tone, ultimately improving vascular structure and function. VSMC vascular smooth muscle cell; Ang II angiotensin II; AT1aR angiotensin type 1 receptor (AT1R) alpha subtypes; Agtr1a AT1R alpha isoform gene; MAs mesenteric arteries; BP blood pressure.
Comparisons of the changes from baseline in vascular endothelial function parameters at 24 weeks among the 3 groups of low, moderae and high uric acid levels achieved with xanthine oxidase inhibitors. After adjustment for confounding factors, such as age, body mass index and concomitant diuretic use, which showed differences among the 3 groups, the change in RHI in the moderate uric acid level group tended to be higher than that in the high uric acid level group and was significantly higher than that in the low uric acid level group.
Uploaders; doctors (31.7%), herbalists/nutritionists (18.3%), independent users (10.6%), chiropractors (6.7%), yoga teachers (4.8%), and others (27.9%). (B) Country of origin; United States of America (58.7%), India (16.3%), Australia (5.8%), United Kingdom (3.8%), others (4.8%), and unknown (10.6%). (C) Usefulness rate by content (%). PT, pharmacological treatment; LC, lifestyle change; AT, alternative treatment.
Antibodies against the (pro)renin receptor residues 47–60 and 200–213 can inhibit pancreatic ductal adenocarcinoma (PDAC) cell proliferation by suppressing Wnt signaling. This study provides 3D structural insights into receptor binding and one-to-many interactions, which underpin the functional versatility of this receptor.
We investigated the familial association of hypertension between offspring and their parents in South Korea. The prevalence of hypertension in boys and girls tended to increase based on the number of parents with hypertension. The risk of having hypertension among offspring was approximately two times higher when one parent was hypertensive and over four times higher when both parents were hypertensive compared to controls whose parents were not hypertensive. OR odds ratio, HTN hypertension, BP blood pressure.
Arterial stiffness progresses with age and is associated with adverse cardiovascular disease events. Studies of associations between statin therapy and arterial stiffness have yielded mixed results. Multi-Ethnic Study of Atherosclerosis (MESA) participants (n = 1242) with statin medication use data at each exam and who had B-mode carotid ultrasound at baseline and Exam 5 after (mean ± [SD]) 9.4 ± 0.5 years were analyzed. Carotid arterial stiffness was measured using distensibility coefficient (DC) and Young’s elastic modulus (YEM). Statin therapy was noted to not be associated with changes in carotid artery stiffness over nearly a decade of follow up regardless of therapy duration or intensity.
Both systolic and diastolic blood pressure had a greater reduction during follow-up in patients who commenced the treatment in autumn/winter than in spring/summer. The seasonality in antihypertensive treatment effect tended to be more prominent in those older than 55 years of age.
This study included 964 apparently healthy (no self-reported chronic illnesses, free from clinical symptoms of CVD) black and white men and women (aged 20–30 years old) from the African-PREDICT study. Cardiovascular risk factors used for stratification included obesity, physical inactivity, tobacco use, high alcohol intake, hyperglycemia, dyslipidemia and hypertension. Participants were divided into low (0 risk factors), medium (1–2 risk factors) and high (≥3 risk factors) CV risk groups. We found lower abundances of collagen type I and III derived peptides in the high compared to the low cardiovascular risk group, which may suggest early alterations in the cardiovascular extracellular matrix.