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Continuous motion monitoring sensitively predicts terminal endpoint in a mouse model of ovarian cancer; the use of motion metrics could reduce animal suffering and be valuable for drug efficacy testing.
In rats, forced running wheel exercise activates an adaptation of the antioxidant system response in skeletal muscle at speeds <16 m/min, whereas it induces oxidative stress at higher speeds in muscle, liver and serum.
Goblet cell–associated antigen passages can deliver luminal substances to antigen-presenting cells to induce antigen-specific T cell responses. This protocol describes how to identify and quantify intestinal epithelial cells that have the capacity to take up luminal substances, by intraluminal injection of fluorescent dextran, tissue sectioning for slide preparation and imaging with fluorescence microscopy.
In this study, Åhlgren and Voikar demonstrate that C57BL/6N and C57BL/6J mice from different vendors show substantial behavioral differences, although they are derived from the same strain. These results suggest that different mouse strains and substrains should be included in experiments to address the lack of reproducibility.