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Exercise during the early active phase leads to more robust bone growth and maturation in young mice, through a mechanism dependent on oxidative phosphorylation.
Jiménez-Blasco et al. show that neurons exhibit moderately low glycolytic rates despite their activity being mainly supported by glucose to preserve redox balance.
Tan et al. identify a regulatory network between colonic EECs and the gut microbiota that controls l-glutamic acid production, appetite and body weight in mice.
Upon nutrient stress in hepatocellular carcinoma, the glycolytic enzyme PFKL facilitates mitochondria tethering to lipid droplets to engage lipid mobilization and ensure nutrient supply.
The metabolite agmatine derived from the gut microbiota contributes to a polycystic ovary syndrome-like phenotype in female mice and inhibits the secretion of glucagon-like peptide-1, thereby contributing to metabolic and ovarian dysfunction.
Sung et al. provide a powerful pipeline based on deep mutational scanning to elucidate the molecular mechanisms of mitochondrial complex I assembly and predict pathogenicity of mutations in complex I assembly factors.
Using a multi-omics approach, the authors examine the molecular drivers of sexual dimorphism in the subcutaneous adipose tissue from sedentary and endurance-trained rats. These data provide a valuable resource for adipose tissue-related research.
Inhibitor of mitochondrial transcription treatment leads to reduced oxidative phosphorylation capacity but increases fatty acid oxidation in the liver, leading to protection from obesity and related pathology.
Sun et al. identify fatty acid binding protein 5 (FABP5) as a driver of obesity-induced hepatocellular carcinoma in mice. FABP5 inhibition is found to predispose transformed cells to death by ferroptosis and to induce a pro-inflammatory tumour microenvironment.
Lakhani et al. offer insight into the metabolic reconfigurations driven in T cells by chimeric antigen receptors (CARs) that differ only in their extracellular domains.
Hauck et al. show that during fasting, nuclear receptor corepressors 1 and 2 act together to activate the transcription of target genes, which is critical for the physiological response to fasting in mice.
The authors develop a metabolic engineering strategy for improving polyketide production of industrial interest and discovering new natural products in bacteria.
Rohm et al. show that small extracellular vesicles from adipose tissue macrophages from obese rosiglitazone-treated mice ameliorate glucose tolerance and insulin sensitivity in obese mice, while circumventing the adverse effects of rosiglitazone.
Kim et al. discover a subset of neurons that innervate the Drosophila intestine and act as postprandial taste-independent sensors for sodium, directing a behavioural preference for sodium following salt deprivation.
Klingelhuber, Frendo-Cumbo et al. develop a proteomic atlas elucidating the intracellular spatiotemporal changes in protein levels and localizations during human adipogenesis.
In mice, disruption of circadian rhythms during pregnancy aggravates neonatal inflammation via metabolic reprograming of myeloid cells in the offspring.
A new methodology uses intravital time-gated mid-infrared optoacoustic signals for accurate non-invasive measurements of glucose concentrations in blood-rich volumes of the skin.