Reviews & Analysis

The continued search of high-performance semiconductors for organic electronics calls for smart molecular designs. Here, Yinget al. review the recent development of synthesizing regioregular narrow bandgap conjugated polymers and the effect of regioregularity on transistor and photovoltaic performance.

Vascular endothelium possesses remarkable plasticity in response to cues from its surroundings, leading to great heterogeneity of endothelial cells in different vascular beds. Here the authors explain the molecular basis of endothelial plasticity during embryogenesis and in various diseases.

The Human Proteome Project aims to catalogue the ∼20,000 proteins encoded by the human genome. In this review, Bakeret al. focus on the missing proteins, proteins that lack high stringency proteomic evidence, and launch MissingProteinPedia, a database aimed at accelerating the search for missing proteins.

Earthquake prone areas are now routinely monitored by satellites, which can map surface rupture and distribution of slip on faults. Here Elliottet al. review the latest advances in the field of spacebased earthquake observations showing how this is used to understand active tectonic processes.

With the continued miniaturization of electronics, there are increasing efforts to engineer small, powerful energy storage devices. Here the authors review the cutting edge of this rapidly developing field, highlighting the most promising materials and architectures for our future energy storage requirements.

Photosynthetic microalgae could provide an ecologically sustainable route to produce solar biofuels and high-value chemicals. Here, the authors review various optical management strategies used to manipulate the incident light in order to increase the efficiency of microalgae biofuel production.

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population expanded in cancer and other chronic inflammatory conditions. Here the authors identify the challenges and propose a set of minimal reporting guidelines for mouse and human MDSC.

Sex chromosome evolution begins when recombination between a homologous pair of chromosomes is halted. Here, Wright et al.review our current understanding of the causes and mechanisms of recombination suppression between incipient sex chromosomes and suggest future directions for the field.

Recent work has shown that quantum mechanical effects in plasmonic nanogap structures become important as the gap distances approach the subnanometre length-scale. Here, the authors review the major findings which challenge the classical picture of these structures and discuss future directions for the field.

The marriage of photochromic molecules with the rapidly expanding portfolio of nanocarbons is providing new multifunctional and responsive nanomaterials. Here, the authors review recent progress in such materials' fabrication and their possible implementations, and suggest future directions of study.

The mid-Pliocene Warm Period (mPWP), analogous to future climate conditions, is considered a test-bed for the predictive capability of climate models. Here, Dowsett et al. review our understanding of the mPWP and discuss recent and future advances in the context of proxy data/model integration.

Water is the most common liquid in nature, with unusual properties that could be linked to the peculiar hydrogen-bonding network holding the molecules together. Here, Nilsson and Pettersson review recent progress in searching the connections between local configurations and thermodynamic responses of water.

Belowground soil biota play key roles in maintaining proper ecosystem functioning, but studies on their extinction ecology are sparse. Here, Veresoglou et al. review the risks to soil biota posed by global change, and highlight the technical challenges involved in identifying extinction events.

Hierarchically organized zeolites are materials retaining the crystalline order and associated functionality of bulk zeolites while also integrating a multilevel pore network. Here, the authors review the raft of techniques applied to characterize their crystal, pore and active site structures.

There is currently intensive research underway into the development of non-layer structured two dimensional nanomaterials. Here, Zhang et al.review the research progress on the most promising wet-chemical synthesis methods as well as a wide range of applications of this unique class of materials.

There are many examples in nature of biological materials having developed interesting mechanical properties to enhance their functional performance. Here, Egan et al. review these materials and how they can inspire the design of biomimetic mechanical systems.

The observation of neutrino oscillations indicates that neutrinos have mass and that their flavours are quantum mechanical mixtures. Here, the authors review the past, present and future contributions of nuclear reactor-based neutrino oscillation experiments, their accomplishments and the remaining challenges.

Carbon dioxide is an abundant and easily available source of carbon, produced as a waste product in large quantities worldwide. Here, the authors review recent work on activating and reacting carbon dioxide for use as a building block in organic synthesis.

The unique electrical, mechanical and physical properties of two-dimensional materials make them attractive candidates in flexible nanoelectronic systems. Here Akinwande et al.review the literature on two-dimensional materials in flexible nanoelectronics, and highlight barriers to their full implementation.

Proteins are subject to continuous and complex quality-control mechanisms, which ensure integrity of the proteome. Vilchez et al.review how a demise in these processes, collectively referred to as proteostasis, is linked to organismal ageing and the development of age-associated diseases.