Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Here the authors review evidence suggesting that cocaine-induced changes in orbitofrontal cortex disrupt the representation of states and transition functions that form the basis of flexible behavioral control, resulting in reliance on less flexible control systems and consequently in the pattern of maladaptive behaviors associated with cocaine addiction.
