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An artificial intelligence-powered microscope able to detect tumor cells in histopathology slides holds promise for accelerating pathology workflows for cancer diagnosis
Genetic cell-lineage tracing studies in mice are crucial for delineating the contribution of stem and progenitor cells to different cell types, both in disease states and after regenerative therapy. He et al. have developed new genetic lineage-tracing systems that provide more definitive results than the commonly used Cre-based system and show that this new technology can resolve current controversies in the field, as demonstrated by lineage-tracing studies in the heart and liver.
By surgically directing the vascular delivery of decellularization reagents, the in situ decellularization of desired organs or tissues in mice can be achieved, enabling detailed imaging and characterization of the intact extracellular matrix, including in the cancer metastatic niche.
A method enabling copy-number analysis of single cells from formalin-fixed paraffin-embedded samples is described, validated and applied to analyze samples of synchronous ductal carcinoma in situ and invasive breast carcinoma.
In a new mouse model of multiple myeloma, mice expressing the human versions of six proteins important for hematopoietic function were able to support the growth of primary human multiple myeloma xenografts, including both preneoplastic and malignant plasma cells.
A protocol is developed to enable the differentiation of microglial-like cells from human pluripotent stem cells, which are shown to resemble primary human microglia, integrate into 3D neuronal cultures, and perform phagocytic and injury-response functions.
Mice bearing ossicles containing human bone marrow stromal cells enable improved leukemia engraftment and detection of high frequencies of human leukemia-initiating cells.
Fixed-tissue chromatin immunoprecipitation sequencing (FiT-seq) enables accurate detection of histone marks on chromatin extracted from formalin-fixed paraffin-embedded (FFPE) tissue samples.
Human pluripotent stem cells can be differentiated into exocrine pancreas progenitor organoids, allowing studies of development and pancreatic cancer modeling.
A pipeline incorporating genetic fine mapping, epigenome editing, and genome editing enables functional analysis of disease-associated SNPs located in non-protein-coding regions of the genome.
A method for converting biopsy-size tissue samples into digital files containing the mass spectrometry–measurable proteome of the sample will allow analysis and re-analysis of limited tissue samples.
Development and validation of a genetically encoded system in which gene expression is regulated remotely and noninvasively by either low-frequency radio waves or a static magnetic field.
Georgiou and colleagues describe a single-cell, emulsion-based approach for the high-throughput determination of the paired antibody variable heavy and light chain (VH-VL) repertoire encoded by the more than 2 × 106 B cells in human peripheral blood samples.