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The authors uncover a role for the proteostasis modulator AIRAPL as a tumor suppressor in myeloproliferative malignancies, through its regulation of IGFR stability. The results ascribe a biological function to AIRAPL, and they implicate prosteostatic deregulation as an oncogenic mechanism in myeloid transformation, thus suggesting potential novel therapeutic strategies.
The authors develop a new method to mine genomic cancer data to uncover complex indels. These simultaneous deletions and insertions have been over-looked by previous sequencing data analysis methods, and the Pindel-C algorithm uncovers new information about their potential contribution to tumorigenesis.
A small-molecule inducer of apoptosis is able to kill senescent cells in the bone marrow of irradiated or aged mice, thereby improving hematopoietic stem cell function.
In the past year, we have witnessed a flurry of debates in the biomedical arena, from the uproar surrounding price gouging to the ethical hand-wringing over the use of CRISPR-Cas9 technology for genome editing. Beyond these topics, 2015 also made news with vaccine mandates, epigenetic mapping and even an accidental shipment of anthrax.
This year's newsworthy drugs made strides against cancer, heart disease and more. Some drugs made headlines for their inability to succeed in clinical trials, and others are still waiting, stuck in limbo, for a chance to move forward in the pipeline. Here is a look at a few of them.
A new study provides a rationale for the use of poly (ADP-ribose) polymerase (PARP) inhibitors to trigger irreparable DNA damage as a therapeutic approach in acute myeloid leukemia (AML). It also provides support for combining PARP inhibitors with agents that reduce HOXA9 protein levels.
Aging is receiving more attention as a risk factor for human disease. With the correct modeling of human heterogeneity and consideration of the environmental factors involved in the aging process, we may be able to delay the onset of human disease.
Our list of newsmakers this year includes some standout personalities, from a price-hiking, former hedge fund manager to a persistent and now-well-recognized immunotherapy advocate.
Duchenne muscular dystrophy (DMD) is a devastating X-linked disease that is characterized by progressive muscle degeneration and caused by mutations in dystrophin. Dystrophin is critical for myofiber structural integrity, but a new study reveals an additional important role for this protein in muscle stem cells.
This year saw a whirlwind of insights gleaned into topics ranging from heart cell proliferation to organoid modeling. Here are a few of the research papers detailing some of these intriguing discoveries.