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Verheyen and Gottardi revisit two seminal papers by the Basler, Peifer and Clevers labs elucidating the role of nuclear β-catenin in Wnt signal transduction through its interaction with TCF at Wnt target genes.
Claire Durrant reminds us of the importance of studying the physiological roles of proteins and their aggregates to understand their roles in disease and inform therapies, discussing a 2008 paper on amyloid-β from the Arancio lab.
Stephanie Moon discusses findings that revealed that ribosome stalling can lead to the suppression of translation initiation in the brain, delaying the onset of neurodegeneration.
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of cellular senescence and its effect on physiology and ageing, shaping the future of this research field.
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the importance of RNA transport for development.
Emily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted our understanding of the functionality of transcription factors.
Ernst and Renne highlight two papers, one that discovered and another that structurally defined the ER–mitochondria encounter structure (ERMES) that facilitates the exchange of lipids between the ER and mitochondria.
Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochiantz and colleagues has inspired researchers of various backgrounds.
Bulut-Karslıoğlu remembers the publication of two seminal papers that described bivalent chromatin and how this discovery continues to affect research to this day.
Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with postnatal synapse maturation, suggesting that it contributes to brain function.