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DNA damage repair is in the spotlight this year — the Nobel Prize in Chemistry 2015 was awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar “for mechanistic studies of DNA repair”.
The ubiquitylation enzyme cullin 3 and its adaptor KBTBD8 mediate stem cell specification into neural crest by modulating the translation of a specific set of mRNAs.
Current research illustrates that various proteins, implicated in both physiological and pathological processes, can undergo phase separation to form liquid droplets.
The orientation of CCCTC-binding factor (CTCF)-binding sites located in enhancers and promoters dictates the directionality of CTCF binding and thus chromatin topology and gene expression.