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In this Comment, the authors draw attention to the role of partial order in biomolecular condensates and propose that cooperative, ordered interactions between condensate components could underlie the formation and function of these diverse macromolecular assemblies.
Suppressing ovulation protects against chromosomal abnormalities in ageing mouse oocytes, which can be partly explained by increasing REC8–cohesin retention on chromosomes.
Izabela Sumara highlights the work by Beck and colleagues that identified a pathway for the biogenesis of nuclear pore complexes, which involves annulate lamellae and biomolecular condensates containing nucleoporins.
Rippe and Papantonis suggest that intrinsically disordered regions in transcription-relevant factors underlie the formation of both ‘transcriptional condensates’ and ‘transcription factories’.
The pathogenicity of SARS-CoV-2 and respiratory syncytial virus (RSV) involves mechanisms of liquid–liquid phase separation, which can be explored as targets for new antiviral therapeutics.
Apoptotic hair follicle stem cells contribute to tissue regeneration by producing WNT3, which promotes cell proliferation, enlarging the stem cell pool.
Eric Wang’s familial connection to disease raised tension between efforts devoted to fundamental versus translational research — until he realized both synergize.
In response to replication stress, TOPBP1 is recruited by Treacle to nucleoli, where the two proteins facilitate the stress response and help maintain the transcription of rRNA genes.
Torrino et al. show that the stiffness of the extracellular matrix regulates microtubule posttranslational modification via glutamylation, which impacts microtubule dynamics and cell invasiveness.
Nuclear condensates of m6A-methylated mRNAs with their ‘reader’ YTHDC1 prevent the degradation of acute myeloid leukaemia-promoting mRNAs by the exosome.
Elif Nur Firat-Karalar brings to our attention the early works by Sergei Sorokin that paved the way for research into the biogenesis and function of primary cilia.
The histone reader PHF7 binds to cardiac super-enhancers and is a strong activator of the reprogramming of adult cardiac fibroblasts to induced cardiac-like myocytes.
