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  • Cyclin A destabilizes kinetochore-microtubule attachments during prometaphase to ensure faithful chromosome segregation.

    • Kim Baumann
    Research Highlight

  • TERRAs form RNA-DNA hybrids at telomeres that maintain telomere length in the absence of telomerase.

    • Rachel David
    Research Highlight

  • The first chaperonin was discovered in plants in 1980.

    • F. Ulrich Hartl
    • Manajit Hayer-Hartl
    Journal Club

  • It is possible to obtain totipotent iPS cellsin vivo as well as to increase in vitroreprogramming efficiency to almost 100%.

    • Kim Baumann
    Research Highlight

  • Gα subunits of G protein-coupled receptors (GPCRs) transduce changes in intracellular pH to changes in GPCR signalling

    • Kirsty Minton
    Research Highlight

  • The studies that implicated CIN and aneuploidy in ageing.

    • Kristin A. Knouse
    • Angelika Amon
    Journal Club

  • Lamin A upregulation in response to a tense extracellular environment may help to protect the nucleus.

    • Alison Schuldt
    Research Highlight

  • The identification of the 'Q body' as a dynamic quality control structure for misfolded proteins.

    • Katharine H. Wrighton
    Research Highlight

  • Proteasomal processing of Def1 allows it to target an RNA polymerase subunit for degradation during stress.

    • Rachel David
    Research Highlight

  • Cohesin affects interphase chromosome architecture and transcription factor positioning.

    • Kim Baumann
    Research Highlight

  • TSC inhibits mTORC1 in response to oxidative stress in peroxisomes.

    • Rachel David
    Research Highlight

  • The inability to regenerate heads from tail fragments in three planarian species can be reversed by downregulating WNT–β-catenin signalling.

    • Kim Baumann
    Research Highlight

  • GTSF1 is a key cofactor in Piwi–piRNA-mediated transposon silencing inDrosophila melanogaster.

    • Rachel David
    Research Highlight