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An isoform of the RNA-editing protein ADAR1 is shown to be activated through nuclear export in response to cellular stress and to protect anti-apoptotic mRNAs from Staufen 1-mediated decay.
Expansion of polyglutamine tracts in proteins interferes with the process of autophagy and may contribute to the pathology of neurodegenerative diseases.
Novoa, Mason and Mattick propose to use phage display technology and direct sequencing through nanopores to facilitate systematic interrogation of RNA modifications.
The ESCRT-III complex is shown to counteract the loss of plasma membrane integrity in cells undergoing necroptosis, thereby preventing or delaying cell death.
Worms with impaired H3K4 trimethylation have an extended lifespan, which is associated with the accumulation of monounsaturated fatty acids in their intestines.
Allan Jacobson reminds us of how a study by Deveret al. published in 1992 connected several data on translational regulation, bringing attention to its crucial role in the regulation of gene expression.
In mouse muscle cells, an isoform of EZH1 — a subunit of Polycomb repressive complex 2 (PRC2) — sequesters another subunit in the cytosol, thereby inhibiting PRC2 function.
Cold stress activatesArabidopsis thalianaplasma membrane-localized CRPK1, which leads to 14-3-3 proteins entering the nucleus and promoting the degradation of CBF transcription factors, thus attenuating the cold-induced response.
Kai Simons discusses how MDCK cells grown on semi-permeable filters have become a model for studying apico-basal cell polarity with the use of viruses.
Mechanical tension is shown to contribute to the establishment of the cell polarity axis in plant epidermal stem cells, which is important for regulating asymmetric cell division.
Two studies report new methods for studying the 3D genome — one captures three-way contacts and the other calculates 3D structures of genomes in single cells.
