News & Comment

Editing the protein sequence of the transcription factor SKN-1A/Nrf1 regulates its function and the expression of proteasome subunits.

Glucose deprivation induces ER stress, which enhances mitochondrial respiration by promoting the assembly of respiratory supercomplexes.

Simoneau and Scott ask that researchers provide complete descriptions of their choices and parameters of RNA-seq data analysis.

Susana Godinho discusses a 1996 paper by Heald et al. on the organization of microtubules into bipolar spindles.

Jesús Gil discusses the first evidence for cellular senescence being associated with ageing, and how these studies opened new routes for basic and translational research.

Michael Levin and colleagues discuss the need to rethink how the causes of cell biological processes are being identified.

The serotonylation of histone H3 Gln5 promotes transcription of neuronal genes during neuronal cell differentiation, by potentiating the binding to promoters of the transcription factor TFIID.

A group of mesenchymal stem cell transcription factors promotes osteogenesis and represses adipogenesis.

Two studies in Science show that biomolecular condensates of membrane-associated signalling complexes increase the residence of signalling effectors within these complexes.

Two independent studies from Science report that hypoxia causes histone hypermethylation by direct modulation of histone lysine demethylases.

Channing Der and Kirsten Bryant discuss recent work leading towards therapeutic targeting of autophagy in pancreatic cancer.

DNA replication of under-replicated loci can occur after mitosis in 53BP1-contaning nuclear bodies and is required for genome stability.

Four studies provide new insights into the mechanism, functions and regulation of the cGAS–STING pathway.

High-throughput FISH analysis reveals that chromatin interactions are highly variable between cells and between alleles in individual cells.

Three studies provide new insights into the mechanisms responsible for genome remodelling and changes in gene expression associated with senescence.

Lipin 1 and ARF1 control SREBP trafficking, processing and activity to regulate lipid synthesis in response to mechanical cues from the extracellular matrix.

Jan Philipp Junker discusses new insights into mechanisms of transcriptional compensation in mutants.

Cells can efficiently invade the tissue in the absence of metalloproteinases by physically breaching the basement membrane.

Cells in telomere crisis undergo cell death through autophagy, which is triggered by chromosome breakage and transduced by the cGAS–STING pathway.

Palmitoylation-driven partitioning of importin-α at the plasma membrane contributes to intracellular scaling.