News & Comment

A new study shows that the mitochondrial transcription elongation factor TEFM serves as a molecular switch between replication and transcription.

PRDM16 activates brown adipose-selective genes through direct interaction with the Mediator complex subunit MED1 at enhancer regions and the regulation of chromatin architecture.

DNA topoisomerase 1 mediates single-strand nicks to relieve the inhibitory effect of DNA supercoiling on enhancer-dependent transcription.

Robert Grosse discusses how optogenetic strategies have the potential to advance our understanding of protein function and localization in individual living cells.

A new study shows that phosphorylation regulates the folding, and thus biological function, of the intrinsically disordered protein 4E-BP2.

Kapitein and colleagues have used an optically controlled system that couples organelles and motor proteins to study the dynamics and roles of organelle transport.

A robust method to induce primordial germ cells from human pluripotent stem cells has been developed, highlighting the importance of SOX17 in the specification of the human germline.

Two studies have determined the molecular mechanisms that underlie a specific clathrin-independent pathway for the internalization of activated surface receptors and bacterial toxins.

The RNA-binding protein Elav is recruited in the fruit fly to promoter regions, possibly by paused RNA polymerase II, to promote alternative polyadenylation.

Chromatin decondensation is sufficient to induce the relocation of loci from the periphery to the centre of nuclei.

Stephen J. Royle describes a cutting-edge study that provided definitive evidence for the first time that the kinetochore fibre is a bundle of parallel microtubules.