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DNA N6-adenosine methylation is a transgenerational epigenetic modification that confers mitochondrial stress adaptation in the nematode Caenorhabditis elegans.
David Barford discusses how the template model for MAD2 activation in the spindle assembly checkpoint represented a new concept for generating and propagating intracellular signals.
The RNA-binding protein TIS11B forms a membraneless organelle, the TIS granule, in an endoplasmic reticulum (ER) subdomain termed the TIS granule–ER (TIGER) domain, which facilitates 3ʹ UTR-mediated protein–protein interactions that regulate protein trafficking.
Transcription elongation supported by the super elongation complex, and H3K9 methylation and gene repression by G9a mediate the oncogenic function of Myc.
Adriano Aguzzi discusses the endeavours of the Gitler team to identify the causes underlying the fatal human neurological disease amyotrophic lateral sclerosis (ALS).
DNA double-strand breaks at active genes are repaired by a dedicated homologous recombination mechanism involving R-loop formation and RAD52 recruitment.
Dan Fletcher’s lab comments on the unique properties of membranes at cell–cell adhesions, suggesting that cell–cell interfaces are a separate cellular compartment.
3′uridylation by TUT4 and TUT7 is shown as a post-transcriptional mechanism restricting retrotransposition of LINE-1 elements and also replication of animal RNA viruses.