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Blastoids (blastocyst-like structures) that accurately model human blastocyst development and are capable of implantation are generated, potentially opening up new avenues for basic and clinical research.
Kaneshige et al. show that skeletal muscle-resident mesenchymal progenitors relay the mechanical signal of muscle overload to muscle stem cells to induce their proliferation.
Bracken and Goodall discuss why epithelial–mesenchymal transition (EMT) has so many regulators, but also consider whether many of these may be ‘false positives’.
DNA damage accumulation in zebrafish neurons during wakefulness is detected by Parp1, which induces a homeostatic drive to sleep and repair the damage.
Lengefeld et al. show that haematopoietic stem cell enlargement explains, at least in part, the reduction of tissue regenerative potential with ageing.
Zimmerli and Allegretti et al. show, in fission yeast, that nuclear pores constrict under energy deprivation or osmotic stress, which is linked to a reduction in nuclear membrane tension.
Appreciation of intrinsically disordered regions of proteins is not a novel phenomenon: Frixione and Ruiz-Zamarripa recollect that they were discussed already in the mid-twentieth century.
Prachee Avasthi highlights how a 1969 study by Rosenbaum and colleagues on Chlamydomonas provided a framework for the understanding of the structure and function of cilia.
Betti et al. show that plants can take up microRNAs generated by other plants, and that these exogenous miRNAs are active in silencing the expression of their target genes.
Christine Mummery and Eric Anthony discuss some key changes to the ISSCR Guidelines for Stem Cell Research and Clinical Translation, which concern, among other experimental procedures, the culturing of human embryos, genome editing and mitochondrial replacement techniques.
tiRNA-containing extracellular vesicles produced by osteoblasts in the bone marrow are taken up by granulocyte–monocyte progenitors, which promotes their proliferation, increasing host immunity.
Tau oligomers bind to m6A-modified RNA transcripts in the cytoplasm via the linker RNA-binding protein HNRNPA2B1; such complexes are found in individuals with Alzheimer disease and are part of a stress response that represses translation.