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A reduction in mechanical loading of the skeleton resulting from aging or a sedentary lifestyle can confer an increased risk of fracture through reductions in bone quantity and quality. Not only are mechanical signals crucial in defining and maintaining bone mass, but they also have the potential—in a high-frequency, low-intensity form—to be used in the treatment of osteoporosis.
The epidemiology and clinical profile of gout have changed considerably over the past two decades. In this context, advances in our understanding of the pathogenesis of hyperuricemia and gouty inflammation, and developments in therapeutic options for patients with gout are discussed in this Review.
