Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Evidence is mounting that the cholinergic pathway is involved in the pathogenesis of rheumatoid arthritis and other immune-mediated inflammatory disorders. This timely article provides an overview of the role of the vagus nerve and α7 nicotinic acetylcholine receptor in this pathway, and highlights novel strategies that could exploit these targets in the treatment of rheumatic diseases.