Featured
-
-
Article
| Open AccessSubventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke
The functions of newborn cells arising from the subventricular zone in response to stroke have been unclear. Here, the authors show that cells migrating from the subventricular zone after stroke promote brain repair and functional recovery in mice.
- Michael R. Williamson
- , Stephanie P. Le
- & Michael R. Drew
-
Article
| Open AccessPost-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis
Here the authors identify RNA-binding protein MEX3A as a post-transcriptional regulator of quiescence and differentiation signatures at critical transitions along the murine subependymal neurogenic lineage
- Ana Domingo-Muelas
- , Pere Duart-Abadia
- & Isabel Fariñas
-
Article
| Open AccessImmature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb
New olfactory sensory neurons (OSNs) wire into highly organized olfactory bulb circuits throughout life. Here, the authors show that immature OSNs provide behaviourally relevant sensory input to olfactory bulb neurons that is functionally distinct from that provided by mature OSNs.
- Jane S. Huang
- , Tenzin Kunkhyen
- & Claire E. J. Cheetham
-
Article
| Open AccessKetamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice
Rawat et al. demonstrate that activation of adult-born immature hippocampal neurons is necessary and sufficient for the acute antidepressant effects of low-dose ketamine in mice.
- Radhika Rawat
- , Elif Tunc-Ozcan
- & John A. Kessler
-
Article
| Open AccessSingle-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors
The decline in neurogenesis following birth is accompanied with a quiescent state characteristic of neural progenitors of the adult brain. Here, the authors identify the Wnt pathway antagonist SFRP1 as a potential signal that promotes quiescence and show that its inhibition stimulates stem cell activation.
- Vanessa Donega
- , Astrid T. van der Geest
- & Elly M. Hol
-
Article
| Open AccessLocomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord
The mechanisms stimulating adult neurogenesis are unclear. Here, the authors show the contribution of cholinergic and GABAergic signalling within the locomotor network to spinal cord neurogenesis during homeostasis and regeneration, showing neurogenesis depends on circuit activity in the adult zebrafish.
- Weipang Chang
- , Andrea Pedroni
- & Konstantinos Ampatzis
-
Article
| Open AccessAdult-born neurons immature during learning are necessary for remote memory reconsolidation in rats
The role of adult hippocampal neurogenesis in memory reconsolidation is unclear. Here, the authors show that memory retrieval activates both immature and mature adult-born neurons. However, only adult-born neurons immature during learning are required for remote memory reconsolidation in rats.
- Marie Lods
- , Emilie Pacary
- & Sophie Tronel
-
Article
| Open AccessA critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy
Adult-born granule cells integrate in hippocampal circuitry and contribute to hippocampal function. Here, the authors show that a critical period of neuronal activity regulates aberrant neurogenesis to rewire hippocampal circuitry and drive seizures in a mouse model of epilepsy.
- Zane R. Lybrand
- , Sonal Goswami
- & Jenny Hsieh
-
Article
| Open AccessHippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy
The dentate gyrus is involved in synchronous discharges and seizures, but its microcircuit functional organization in TLE is unclear. Here, the authors show that interictal discharges recruit specific granule cell ensembles dominated by adult-born immature neurons.
- F. T. Sparks
- , Z. Liao
- & A. Losonczy
-
Article
| Open AccessIncreasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
Ageing affects several brain areas causing a decrease in cognitive abilities and memory. We find that increasing the endogenous potential of the hippocampus to generate new neurons throughout life rejuvenates learning and memory, indicating that neural reserves can be exploited during ageing to compensate for age- or disease-related cognitive impairments.
- Gabriel Berdugo-Vega
- , Gonzalo Arias-Gil
- & Federico Calegari
-
Article
| Open AccessRBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
Therapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contributes substantially to neuroregeneration after adult HI injury, specifically in the subventricular zone and subgranular zone.
- Xinzhou Zhu
- , Jingyi Yan
- & Sven Wellmann
-
Article
| Open AccessImmature excitatory neurons develop during adolescence in the human amygdala
Immature excitatory neurons in the human amygdala persist throughout life and could be a substrate for plasticity. Here the authors find evidence that the maturation of these cells may be accelerated during puberty.
- Shawn F. Sorrells
- , Mercedes F. Paredes
- & Arturo Alvarez-Buylla
-
Article
| Open AccessReducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
Loss of fragile X mental retardation protein (FMRP) leads to fragile X syndrome, associated with cognitive dysfunction. Here the authors show that mice lacking FMRP show reduced hippocampal neurogenesis and cognitive deficits, which can be rescued by reducing histone acetylation.
- Yue Li
- , Michael E. Stockton
- & Xinyu Zhao
-
Article
| Open AccessUncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus
Multiciliated ependymal cells (ECs) in the mammalian brain are glial cells facilitating cerebral spinal fluid movement. This study describes an inherent cellular plasticity of ECs as maintained by Foxj1 and IKK2 signaling, and shows resulting hydrocephalus when EC de-differentiation is triggered.
- Khadar Abdi
- , Chun-Hsiang Lai
- & Chay T. Kuo
-
Article
| Open AccessEnvironmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus
Environmental enrichment has functional and molecular effects on mammalian hippocampus. Here, Zhang and colleagues show that environmental enrichment of mice is correlated with dorsal-ventral asymmetry in transcription and DNA methylation of the dentate gyrus.
- Tie-Yuan Zhang
- , Christopher L. Keown
- & Michael J. Meaney
-
Article
| Open AccessImpairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
Cholinergic neurons in the diagonal band of Broca degenerate early in Alzheimer’s disease. Here the authors show that in healthy mice, these cholinergic inputs innervate newborn neurons in the hippocampus, and that loss of this innervation in an Alzheimer’s disease model leads to impairments in spatial memory.
- Houze Zhu
- , Huanhuan Yan
- & Youming Lu
-
Article
| Open AccessTrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
The precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.
- Zhenzhong Ma
- , Tong Zang
- & Luis F. Parada
-
Article
| Open AccessOxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons
Oxytocin (OXT) has been implicated in adult neurogenesis. Here the authors show that CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons; activation of OXT signaling in CA3 pyramidal cells promotes the survival and maturation of newborn neurons in the dentate gyrus in a non-cell autonomous manner.
- Yu-Ting Lin
- , Chien-Chung Chen
- & Kuei-Sen Hsu
-
Article
| Open AccessStage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on PlexinC1, whereas in adult-born neurons, it promotes dendrite growth through β1-integrins.
- Bart C. Jongbloets
- , Suzanne Lemstra
- & R. Jeroen Pasterkamp
-
Article
| Open AccessPrincipal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb
The mechanism by which adult-born neurons quickly adjust olfactory bulb network functioning is not understood. Here the authors describe a novel form of structural plasticity in which mature spines relocate toward active mitral cell dendrite along spine head filopodia via AMPA and BDNF mediated signalling.
- Vincent Breton-Provencher
- , Karen Bakhshetyan
- & Armen Saghatelyan
-
Article |
Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway
Methyl-CpG-binding protein 2 (MeCP2) is phosphorylated in neurons in response to neuronal activity. Here, Li et al.show that it is also phosphorylated by aurora kinase B in neural progenitor cells, and cell cycle-dependent phosphorylation of MeCP2 regulates the balance between proliferation and differentiation via Notch signalling.
- Hongda Li
- , Xiaofen Zhong
- & Qiang Chang