Adult stem cells articles within Nature Communications

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  • Article
    | Open Access

    The downstream effector of the Hippo pathway, YAP, is a critical regulator of both normal and cancer stem cell properties. In this study, the authors show that in basal-like breast tumors YAP forms a complex with SRF and together they induce a mammary stem cell gene signature through the transcriptional activation of IL-6.

    • Tackhoon Kim
    • , Suk-Jin Yang
    •  & Dae-Sik Lim

  • Article
    | Open Access

    The first haematopoietic stem and progenitor cells arise from the hemogenic endothelium of arterial vascular beds. Here the authors describe the mechanism that regulates the endothelial-to-haematopoietic transition and show that Sox17 and Notch1, genes critical to arterial endothelium identity, are also crucial repressors of haematopoietic fate.

    • Carlos O. Lizama
    • , John S. Hawkins
    •  & Ann C. Zovein

  • Article |

    Central to the lineage commitment of multipotent mesenchymal stem cells is the nuclear receptor PPARγ, the master regulator of adipogenesis. Here the authors use a variety of structural approaches to rationally design PPARγ inverse agonist SR2595, and demonstrate its ability to promote osteogenesis.

    • David P. Marciano
    • , Dana S. Kuruvilla
    •  & Patrick R. Griffin

  • Article
    | Open Access

    Skeletal muscle satellite cells are important for muscle regeneration, but their regulatory mechanisms are largely unknown. Here the authors identify arginine methyltransferase Prmt5 as a key regulator of satellite cell maintenance and function in adult mice, and show that Prmt5 acts mainly but not exclusively on the cell cycle inhibitor p21.

    • Ting Zhang
    • , Stefan Günther
    •  & Thomas Braun

  • Article |

    Increased levels of haematopoietic stem and progenitor cells in the blood have been linked to some forms of organ failure. Here, the authors show that the hormone angiotensin II increases mobilization of haematopoietic stem and progenitor cells by inducing cytoskeletal changes in bone marrow cells.

    • Kyung Hee Chang
    • , Ramesh C Nayak
    •  & Jose A Cancelas

  • Article |

    Satellite cells have important roles in homeostasis and regeneration of skeletal muscles. Urciuolo et al. show that the extracellular matrix protein collagen VI is required for preserving satellite cell self-renewal and muscle regeneration in vitro and in vivoby modulating muscle mechanical properties.

    • Anna Urciuolo
    • , Marco Quarta
    •  & Paolo Bonaldo

  • Article |

    Studying the effects of extracellular matrix stiffening has been impeded because mostin vitromodels are static. Here, dynamic hydrogels are developed that stiffen in the presence of cells and are used to investigate the short-term (minutes-to-hours) and long-term (days-to-weeks) cellular responses to dynamic stiffening.

    • Murat Guvendiren
    •  & Jason A. Burdick

  • Article
    | Open Access

    It has been proposed that stem cells use nonrandom chromosome segregation to avoid the accumulation of replication-induced mutations. Here, the authors examine intestinal epithelial stem cell division and show, using label exclusion and retention assays, that the cells segregate their chromosomes randomly.

    • Marion Escobar
    • , Pierre Nicolas
    •  & Catherine Legraverend

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