Angiogenesis articles within Nature Communications

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  • Article
    | Open Access

    Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.

    • Feng Zhang
    • , Claudia Prahst
    •  & Anne Eichmann

  • Article
    | Open Access

    During vascular development, fibronectin (FN) is polymerized at the basolateral side of endothelial cells. Here Mana et al. propose a model where PPFIA1 drives recycling of the FN receptor, a5β1 integrin, to the cell surface and enables polar secretion and fibrillogenesis of newly synthesized FN.

    • Giulia Mana
    • , Fabiana Clapero
    •  & Donatella Valdembri

  • Article
    | Open Access

    The mechanism underlying endothelial cell responses to BMP signals is unknown. Here, the authors show that the endothelial response to pro-angiogenic BMP ligands is regulated by Notch via its effect on SMAD6, a known inhibitor of BMP intracellular signaling cascade.

    • Kevin P. Mouillesseaux
    • , David S. Wiley
    •  & Victoria L. Bautch

  • Article
    | Open Access

    Circulating Ly6Clo monocytes are thought to be derived from Ly6Chi subset. Here the authors show that Notch signalling is activated in Ly6Clocells and is required for their differentiation, and that Notch ligands that initiate this signalling are provided by a subset of endothelial cells.

    • Jaba Gamrekelashvili
    • , Roberto Giagnorio
    •  & Florian P. Limbourg

  • Article
    | Open Access

    How p53 is restrained in arterial maturation during embryonic development is unclear. Here, the authors show that β-catenin C-terminal interactions inhibit CREB binding protein-mediated acetylation and activation of p53 in smooth muscle cells, and that this function is essential for artery formation.

    • Dario F. Riascos-Bernal
    • , Prameladevi Chinnasamy
    •  & Nicholas E. S. Sibinga

  • Article
    | Open Access

    Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this prediction.

    • Bert Cruys
    • , Brian W. Wong
    •  & Peter Carmeliet

  • Article
    | Open Access

    Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel growth both within and outside in the heart, suggesting a new target for manipulating angiogenesis.

    • Mao Wang
    • , Patrick Sips
    •  & Stuart A Cook

  • Article
    | Open Access

    Heart function after injury improves upon formation of new blood vessels. Here, the authors show that ablating a transcription factor RBPJ in the murine heart increases vascularization and maintains cardiac function after injury by increasing responsiveness to hypoxia, suggesting a new approach to treat heart injury.

    • Ramón Díaz-Trelles
    • , Maria Cecilia Scimia
    •  & Mark Mercola

  • Article
    | Open Access

    Ceruloplasmin has an important role in the stabilization and nuclear transport of HIF-1α, thus regulating VEGF expression. Here the authors show that the transcription factor SARI reduces colorectal cancer growth and angiogenesis in vivoby inducing the degradation of ceruloplasmin, thereby inhibiting the HIFα/VEGF axis.

    • Lei Dai
    • , Xueliang Cui
    •  & Hongxin Deng

  • Article
    | Open Access

    The alternative splicing factor Nova2 is best known for its pivotal function in the brain. Giampietro et al. reveal an important role for Nova2 in the regulation of alternative splicing of transcripts in the vascular endothelium that are crucial for the maintenance of endothelial cell polarity and vessel lumen formation in zebrafish.

    • Costanza Giampietro
    • , Gianluca Deflorian
    •  & Claudia Ghigna

  • Article |

    The regulatory subunits (RI) of protein kinase A (PKA) form a disulfide bond in response to cellular hydrogen peroxide. Here the authors show that disulfide-activation of PKARIa regulates VEGF-induced angiogenesis in mice and may represent a new therapeutic target in diseases with abnormal angiogenesis.

    • Joseph R. Burgoyne
    • , Olena Rudyk
    •  & Philip Eaton

  • Article
    | Open Access

    During the formation of vascular sprouts, Notch activation inhibits proliferation of the stalk ECs via unknown mechanism. Here the authors show that PTEN represents a critical mediator of Notch anti-proliferative response in stalk cells via its phosphatase-dependent and -independent activity.

    • Helena Serra
    • , Iñigo Chivite
    •  & Mariona Graupera

  • Article
    | Open Access

    Blood vessel development depends upon endothelial cell migration and adhesion, which are regulated by Rho-GTPases. Here the authors identify Rho-GTPase guanine nucleotide exchange factors that specifically control lateral filopodial contacts and are required for lumen formation during angiogenesis.

    • Sabu Abraham
    • , Margherita Scarcia
    •  & Georgia Mavria

  • Article
    | Open Access

    Notch signals are crucial for organization of angiogenic sprouting cells into the leading ‘tip’ and trailing ‘stalk’ cells. Here the authors show that endothelial neuropilin-1 quantitatively inhibits TGF-β/BMP signalling, explaining how Notch-mediated regulation of neuropilin-1 specifies endothelial tip and stalk cells.

    • Irene Maria Aspalter
    • , Emma Gordon
    •  & Holger Gerhardt

  • Article |

    Angiogenesis is regulated by dynamic changes in endothelial cell contact. Here, the authors show that signals from endothelial cell junctions affect the subcellular localization and function of Yes-associated protein, ultimately modifying angiopoietin-2 expression and angiogenic activity of endothelial cells.

    • Hyun-Jung Choi
    • , Haiying Zhang
    •  & Young-Guen Kwon

  • Article |

    Pruning of newly formed blood vessels is an important and yet poorly understood aspect of angiogenesis. Here the authors show that endothelial phosphotyrosine-dependent EphrinB2 signalling represses JNK3 function via STAT1, and identify JNK3 as an effector of endothelial cell death and vessel pruning in mice.

    • Ombretta Salvucci
    • , Hidetaka Ohnuki
    •  & Giovanna Tosato

  • Article |

    The role of integrin β1 in angiogenesis is poorly understood. Here, the authors show that integrin β1 regulates murine angiogenesis and adherens junction integrity by controlling VE-cadherin localization, myosin light chain phosphorylation and the function of the Rap1/MRCK and Rho/Rho-kinase pathways.

    • Hiroyuki Yamamoto
    • , Manuel Ehling
    •  & Ralf H. Adams

  • Article
    | Open Access

    Apelin expression is robust in embryonic but not in adult endothelial cells (ECs), where it can be reactivated by hypoxia. Liu et al. show that apelin-driven expression of Cre recombinase in mice can be used for labelling of, or gene ablation in, sprouting but not quiescent ECs in pathologies characterized by hypoxia.

    • Qiaozhen Liu
    • , Tianyuan Hu
    •  & Bin Zhou

  • Article
    | Open Access

    Sprouting of new blood vessels depends on the migration of endothelial tip cells into surrounding tissue. Here the authors reveal the existence of a distinct migratory signalling circuit that guides endothelial cells from developing veins to the leading tip position in developing arteries.

    • Cong Xu
    • , Sana S. Hasan
    •  & Arndt F. Siekmann

  • Article |

    Wnt/planar cell polarity (PCP) signalling regulates angiogenesis in vertebrates. Here the authors show that the E3 ubiquitin ligase PDZRN3 ubiquitinates the PCP-signalling protein Dishevelled 3 to promote Wnt/PCP signalling, directing embryonic and postnatal remodelling of the vasculature in mouse.

    • Raj N. Sewduth
    • , Béatrice Jaspard-Vinassa
    •  & Cécile Duplàa

  • Article |

    Myocardin-related transcription factors (MRTFs) increase muscle growth and regeneration. Here, Hinkel et al. show that MRTFs also promote microvessel growth and maturation in chronic ischaemic disease of the heart or peripheral muscle by increasing the expression of the pro-angiongenic factors, CCN1 and CCN2.

    • Rabea Hinkel
    • , Teresa Trenkwalder
    •  & Christian Kupatt

  • Article |

    Notch1 signalling and the dosage of the Notch1 ligand, Dll4, are critical for vascular development. Here the authors show that the transcriptional repressor, Snail1, is expressed in endothelial cells, where it regulates vascular development by downregulating Dll4 levels and Notch1 signalling during mouse embryogenesis.

    • Zhao-Qiu Wu
    • , R. Grant Rowe
    •  & Stephen J. Weiss

  • Article |

    Cell–cell adhesion molecules and the cytoskeleton determine endothelial cell shape during the formation of blood vessels. Here the authors show that the scaffold protein, amotL2, couples adherens junctions to contractile cytoskeletal proteins to coordinate cellular morphogenesis with aortic lumen expansion.

    • Sara Hultin
    • , Yujuan Zheng
    •  & Lars Holmgren

  • Article
    | Open Access

    The formation of blood and lymph vessels after injury requires precise temporal coordination. Here, the authors show that the small GTPase RhoB induces angiogenesis but inhibits lymphangiogenesis in response to dermal wounding by activating different sets of genes in blood vessels and lymphatic endothelial cells.

    • Damien Gerald
    • , Irit Adini
    •  & Laura E. Benjamin

  • Article |

    Osteoblasts and endothelial cells have important roles in bone regeneration. Kim and colleagues identify the protein DJ-1 as an angiogenic and osteogenic signalling molecule involved in the cross-talk between these cells and show that DJ-1 promotes bone regeneration and fracture healing in mice.

    • Jung-Min Kim
    • , Hong-In Shin
    •  & Pann-Ghill Suh

  • Article |

    Hereditary haemorrhagic telangiectasia (HTT) is caused by mutations in TGFβ/bone morphogenetic protein signalling genes. Here, Benzinouet al. show that variants of PTPN14, a gene within a mouse Tgfb1 modifier locus, associate with pulmonary arteriovenous malformation in HTT patients, shedding light on the molecular aetiology of this disease.

    • Michael Benzinou
    • , Frederic F. Clermont
    •  & Rosemary J. Akhurst

  • Article
    | Open Access

    The Hand1 transcription factor plays a central role in cardiovascular development. Here the authors demonstrate that Hand1 regulates thymosin β4 and that the delivery of synthetic thymosin β4 can rescue some of the vascular defects in Hand1 null mouse embryos.

    • Nicola Smart
    • , Karina N. Dubé
    •  & Paul R. Riley

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