Antigen-presenting cells articles within Nature Communications

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• Article
  30 April 2024 | Open Access

  Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses

  Conventional dendritic cells are playing a pivotal role at the interface of innate and adaptive immunity, but they are a heterogenous group regarding function and regulation. Here, the authors show that although Bcl6-deficiency does not regulate general DC subset identity, Bcl6 expression is required for a specific subset of type 2 DCs in mice, resulting in impaired T helper cell responses and further clarifying molecular players driving DC subset heterogeneity.

  • Hongkui Xiao
  • , Isabel Ulmert
  •  & Katharina Lahl

• Article
  29 April 2024 | Open Access

  Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish

  An adequate immune response is necessary to promote heart regeneration. Here, the authors identified a link between antigen presentation, immune cells, and endocardial cells during the regenerative response to cardiac injury in the adult zebrafish.

  • João Cardeira-da-Silva
  • , Qianchen Wang
  •  & Didier Y. R. Stainier

• Article
  13 March 2024 | Open Access

  Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors

  Response to immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC) remains suboptimal, even for tumors with elevated tumor mutational burden. Here the authors generate a model of NSCLC with enhanced mutational load, showing that, while still resistant to ICIs, hypermutated tumors become sensitive to dendritic cell-targeted therapy.

  • Lucía López
  • , Luciano Gastón Morosi
  •  & Federica Benvenuti

• Article
  20 November 2023 | Open Access

  Brain-to-gut trafficking of alpha-synuclein by CD11c⁺ cells in a mouse model of Parkinson’s disease

  Despite being implicated in several neurological diseases, the gut-brain axis remains poorly understood. Here the authors describe a mechanism of communication between the brain and the gut in a Parkinson’s disease mouse model mediated by CD11c⁺ macrophages.

  • Rhonda L. McFleder
  • , Anastasiia Makhotkina
  •  & Chi Wang Ip

• Article
  18 July 2023 | Open Access

  RUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes

  RUFY proteins are known to regulate autophagy, cytoskeletal dynamics, migration and endosomal trafficking. Here, Char et al. show that iRUFY3 plays a role in perinuclear positioning, phagocyte migration and antigen presentation during Salmonella infection.

  • Rémy Char
  • , Zhuangzhuang Liu
  •  & Philippe Pierre

• Article
  30 May 2023 | Open Access

  Antigen recognition detains CD8⁺ T cells at the blood-brain barrier and contributes to its breakdown

  Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system are early hallmarks of multiple sclerosis. Here, the authors demonstrate that brain endothelial cells cross-present antigen to CD8⁺ T cells, thereby preventing their migration and initiating BBB breakdown.

  • Sidar Aydin
  • , Javier Pareja
  •  & Britta Engelhardt

• Article
  31 January 2023 | Open Access

  Enhancing CAR-T cell functionality in a patient-specific manner

  ‘Manufacturing CAR-T cells is a streamlined and highly regulated procedure involving T-cell-expansion and activation on a standardised platform. Here, the authors show that a personalized approach, taking the phenotypic attributes of individual patients’ T cells into account, leads to more efficient CAR-T cell manufacturing and better CAR-T cell functionality.

  • David K. Y. Zhang
  • , Kwasi Adu-Berchie
  •  & David J. Mooney

• Article
  22 November 2022 | Open Access

  Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity

  Strategies to advance T cell based immune therapies are mostly focusing on the improvement of CD8 T cell effector functions, such as cytotoxicity or recruitment to the tumor. Here authors show that by combining in situ vaccination with oncolytic Newcastle Disease Virus and Flt3L-driven dendritic cell expansion, the anti-tumor T cell response is amplified via increased antigen cross-presentation.

  • Judit Svensson-Arvelund
  • , Sara Cuadrado-Castano
  •  & Joshua D. Brody

• Article
  04 November 2022 | Open Access

  Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer

  Dendritic cells (DC) present tumour antigens to T cells but this process is defective in the tumour microenvironment. Here the authors find that downregulation of cholesterol 25-hydroxylase underlies defective cross presentation of tumour antigens.

  • Zhen Lu
  • , Jinyun Chen
  •  & Serge Y. Fuchs

• Article
  26 May 2022 | Open Access

  Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice

  Adipose immune cells contribute to obesity-related disease, but less is known about weight cycling. Here, authors show that weight loss reduces diabetes risk, but inflammatory adipose immune cell populations persist and may contribute to worsened diabetes risk upon weight regain.

  • Matthew A. Cottam
  • , Heather L. Caslin
  •  & Alyssa H. Hasty

• Article
  11 April 2022 | Open Access

  Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

  Regulated trafficking of major histocompatibility complex class II and CD86 is a prerequisite of antigen presenting cell functionality. Authors show here that ubiquitin-like protein 3 is critically involved in the ubiquitination process that controls trafficking, with wide-ranging immunological consequences.

  • Haiyin Liu
  • , Kayla R. Wilson
  •  & Justine D. Mintern

• Article
  28 October 2021 | Open Access

  Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules

  T cells are selected in the thymus, through interaction with self-antigens, to remove autoreactive cells. Here the authors show that a specialized thymic dendritic cell subset juxtaposes to microvessels, requires CX₃CR1/CX₃CL1 for this positioning, and has processes extruding into the blood stream to sample soluble macromolecules and assist in T cell selection.

  • Elisabeth H. Vollmann
  • , Kristin Rattay
  •  & Ulrich H. von Andrian

• Article
  05 October 2021 | Open Access

  Antigen presentation by lung epithelial cells directs CD4⁺ T_RM cell function and regulates barrier immunity

  The maintenance of T resident memory (T_RM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary T_RM cells within specific locational niches.

  • Anukul T. Shenoy
  • , Carolina Lyon De Ana
  •  & Joseph P. Mizgerd

• Article
  09 August 2021 | Open Access

  FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

  Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable functions as classical dendritic cells, and with therapeutic potentials for cancer and infectious diseases.

  • Vijayashree Mysore
  • , Xavier Cullere
  •  & Tanya N. Mayadas

• Article
  28 June 2021 | Open Access

  Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation

  Type II alveolar cells play central roles in multiple aspects of lung biology. Here the authors show that type II alveolar cells also constitutively express MHCII, exhibit limited MHCII antigen presentation capacity, and are a component of the host response to respiratory viral infection.

  • Sushila A. Toulmin
  • , Chaitali Bhadiadra
  •  & Laurence C. Eisenlohr

• Article
  07 June 2021 | Open Access

  The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

  Myosin II–mediated contractility is required for leukocyte migration. Here, authors show that lysosomes are involved in leukocyte migration by providing the platform where Ragulator complex interacts with the myosin phosphatase Rho-interacting protein (MPRIP) independently of mTORC1 and interferes with the interaction between MPRIP and a subunit of myosin light chain phosphatase (MLCP).

  • Takeshi Nakatani
  • , Kohei Tsujimoto
  •  & Atsushi Kumanogoh

• Article
  19 January 2021 | Open Access

  Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

  Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functionally as potent immune activators upon proper stimuli.

  • Nikos E. Papaioannou
  • , Natallia Salei
  •  & Barbara U. Schraml

• Article
  06 November 2020 | Open Access

  Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

  Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and monocytes in the specific induction of Th1, Th2 or Th17 responses following skin inoculation.

  • Kerry L. Hilligan
  • , Shiau-Choot Tang
  •  & Franca Ronchese

• Article
  24 July 2020 | Open Access

  Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates

  T cell tolerance is established in the thymus via interactions with medullary thymic epithelial cells (mTEC) expressing tissue-restricted self antigens. Here, the authors suggest, using new transgenic mouse lines and single cell transcriptome analyses, that specific mTEC subsets are associated with distinct T cell fates.

  • Marie-Ève Lebel
  • , Marie Coutelier
  •  & Heather J. Melichar

• Article
  27 April 2020 | Open Access

  Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

  Murine ILCs can modulate T cell responses in MHCII-dependent manner. Here the authors show that human ILCs process and present antigens and induce T-cell responses upon exposure to IL-1-family cytokines; along with the article by Lehmann et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation.

  • Anna Rao
  • , Otto Strauss
  •  & Jenny Mjösberg

• Article
  14 April 2020 | Open Access

  Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells

  Kinesin-1 is a motor protein transporting cargo along microtubules. Here the authors show that kinesin-1 is required for antigen cross-presentation and coordinates endosome scission from early endosomes to allow sorting internalized cargoes towards the recycling endosomal or lysosomal compartments.

  • Meriem Belabed
  • , François-Xavier Mauvais
  •  & Gaël Ménasché

• Article
  27 January 2020 | Open Access

  Lymphatic endothelial cells prime naïve CD8⁺ T cells into memory cells under steady-state conditions

  Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8⁺ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8⁺ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.

  • Efthymia Vokali
  • , Shann S. Yu
  •  & Melody A. Swartz

• Article
  18 September 2019 | Open Access

  Lung endothelial cell antigen cross-presentation to CD8⁺T cells drives malaria-associated lung injury

  Severe malaria can be associated with respiratory complications. Here, the authors show that malaria-associated pulmonary vascular damage is a consequence of IFNγ-activated lung endothelial cells capturing, processing, and cross-presenting malaria parasite antigen to specific CD8⁺ T cells induced during infection.

  • Carla Claser
  • , Samantha Yee Teng Nguee
  •  & Laurent Renia

• Article
  29 August 2019 | Open Access

  Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

  In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in cell culture and in an animal model of MS.

  • Leslie Kirby
  • , Jing Jin
  •  & Peter A. Calabresi

• Article
  17 May 2019 | Open Access

  Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance

  Both thymic epithelial cells and dendritic cells present self antigens in the thymus to mediate thymic selection and T cell tolerance. Here the authors quantify, using two-photon live imaging of mouse thymic slices, the relative contribution of these two cell types, as well as the effects of antigen cross-presentation by dendritic cells, during tolerance induction.

  • J. N. Lancaster
  • , H. M. Thyagarajan
  •  & L. I. R. Ehrlich

• Article
  23 April 2019 | Open Access

  Mettl3-mediated mRNA m⁶A methylation promotes dendritic cell activation

  Here the authors examine how m⁶A modification is involved in innate immunity. They show that RNA methyltransferase Mettl3-mediated mRNA m⁶A methylation promotes dendritic cell (DC) activation and function, and in promoting DC-based T cells responses.

  • Huamin Wang
  • , Xiang Hu
  •  & Xuetao Cao

• Article
  08 February 2019 | Open Access

  Intestinal non-canonical NFκB signaling shapes the local and systemic immune response

  Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet constitutive NIK activation is associated with gut inflammation and inflammatory bowel disease.

  • Sadeesh K. Ramakrishnan
  • , Huabing Zhang
  •  & Yatrik M. Shah

• Article
  25 September 2018 | Open Access

  RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells

  Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin. Here the authors show that these immune cells are regulated by retinoic acid receptor alpha (RARα) via simultaneous induction of LC-promoting Runx3 and repression of LC-inhibiting C/EBPβ.

  • Seika Hashimoto-Hill
  • , Leon Friesen
  •  & Chang H. Kim

• Article
  30 August 2018 | Open Access

  Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

  Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34⁺ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their functional maturation and differentiation.

  • A. Laustsen
  • , R. O. Bak
  •  & M. R. Jakobsen

• Article
  28 August 2018 | Open Access

  March1-dependent modulation of donor MHC II on CD103⁺ dendritic cells mitigates alloimmunity

  Donor-derived dendritic cells (do-DC) in the graft can contribute to the induction of alloimmunity and tissue rejection, but how do-DC can be targeted for improving graft survival is unclear. Here the authors show that reducing MHC-II expression on do-DCs by DnaK pre-treatment can decrease the priming of alloimmunity and prolong graft survival in mouse models.

  • Thiago J. Borges
  • , Naoka Murakami
  •  & Cristina Bonorino

• Article
  07 August 2018 | Open Access

  Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

  Human leucocyte antigen E (HLA-E) directly engages NK cells but also presents antigen to CD8⁺ T cells. Here the authors show crystal structures of HLA-E in complex with peptides derived from HIV and Mycobacterium tuberculosis, and describe binding conformations, the positional impact of residues involved and discuss implications for functional presentation to CD8⁺ T cells.

  • Lucy C. Walters
  • , Karl Harlos
  •  & Geraldine M. Gillespie

• Article
  28 March 2018 | Open Access

  Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells

  Autoreactive T cells are removed during their development in the thymus through the functions of medullary thymic epithelial cells (mTEC) and dendritic cells (DC), a process termed negative selection. Here the authors show that mTEC-T cell crosstalk and lymphotoxin α signalling are essential for the proper recruitment of DCs into the thymus.

  • Noëlla Lopes
  • , Jonathan Charaix
  •  & Magali Irla

• Article
  12 February 2018 | Open Access

  Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 ⁺ T cell responses

  Dendritic cell antigen presentation is central to CD8⁺ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and in response to cerebral malaria, picornavirus infection and experimental glioma.

  • Courtney S. Malo
  • , Matthew A. Huggins
  •  & Aaron J. Johnson

• Article
  14 December 2017 | Open Access

  Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

  Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.

  • Filippo Veglia
  • , Vladimir A. Tyurin
  •  & Dmitry I. Gabrilovich

• Article
  11 December 2017 | Open Access

  Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction

  Viral infection and vaccination both induce lasting persistence of antigens for protective responses. Here the authors show that migratory dendritic cells, independent of the transcription factor BatF3 for their development, contribute to “archived antigen” exchange with lymphatic endothelial cells.

  • Ross M. Kedl
  • , Robin S. Lindsay
  •  & Beth A. Jirón Tamburini

• Article
  24 November 2017 | Open Access

  STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

  STIM proteins sense Ca²⁺ depletion in the ER and activate store-operated Ca²⁺-entry (SOCE) in response, a process associated with dendritic cell functions. Here the authors show STIM1 is the major isoform controlling SOCE in mouse dendritic cells and provide a mechanism for its requirement in antigen cross-presentation.

  • Paula Nunes-Hasler
  • , Sophia Maschalidi
  •  & Nicolas Demaurex

• Article
  21 November 2017 | Open Access

  UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

  STIM proteins sense Ca²⁺ depletion in the ER and activate store-operated Ca²⁺ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association of the chaperone molecule UNC93B1 with STIM1.

  • Sophia Maschalidi
  • , Paula Nunes-Hasler
  •  & Bénédicte Manoury

• Article
  09 June 2017 | Open Access

  Different populations of CD11b⁺ dendritic cells drive Th2 responses in the small intestine and colon

  T helper 2 (Th2) cell responses are essential for immunity against parasites, but how Th2 response is modulated in the gut is still unclear. Here the authors show that distinct dendritic cell subsets distinguishable by CD11b, CD103 and IRF4 function in the small intestine or colon to promote Th2 responses.

  • Johannes U. Mayer
  • , Mimoza Demiri
  •  & Simon W. Milling

• Article
  31 May 2017 | Open Access

  HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells

  Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasmacytoid dendritic cell expression of neuropilin-1, thus functionally supporting interaction with Treg cells.

  • Lauren B. Kinner-Bibeau
  • , Abigail L. Sedlacek
  •  & Robert J. Binder

• Article
  12 April 2017 | Open Access

  Cognate antigen engagement on parenchymal cells stimulates CD8⁺ T cell proliferation in situ

  Professional antigen presenting cells (APC) are the major activator of T cells that then hone to sites of inflammation. Using islet cell grafts, here the authors show that parenchymal cells can present antigen to activate CD8⁺T cells at inflammatory sites, coining this a ‘mezzanine response’ distinct from primary and secondary responses associated with professional APCs.

  • Robyn M. Sutherland
  • , Sarah L. Londrigan
  •  & Andrew M. Lew

• Article
  07 November 2016 | Open Access

  Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation

  Saponin-based adjuvants are being explored as vaccine components as they induce high levels of antigen cross-presentation, but it is unknown how. Here the authors show that these adjuvants enhance cross-presentation by driving production of lipid bodies inside CD11b dendritic cells.

  • Martijn H. den Brok
  • , Christian Büll
  •  & Gosse J. Adema

• Article
  27 October 2016 | Open Access

  T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

  Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-recognition of CD1b and a mycobacterial glycolipid.

  • Stephanie Gras
  • , Ildiko Van Rhijn
  •  & Jamie Rossjohn

• Article
  08 December 2015 | Open Access

  Identification and characterization of latency-associated peptide-expressing γδ T cells

  Latency-associated peptide (LAP) is a membrane-bound form of TGF-β1. Here the authors show that LAP marks a subset of regulatory γδ T cells with innate gut-homing properties, which present antigen and induce CD4+ Foxp3+ in Peyer's patches and lamina propria.

  • Rafael M. Rezende
  • , Andre P. da Cunha
  •  & Howard L. Weiner

• Article
  19 April 2011 | Open Access

  Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

  Exosomes released from cells can transfer RNA to recipient cells. In this study, the authors demonstrate that microRNAs in exosomes from T cells can be transferred to antigen-presenting cells during immune synapsis, and that this can alter gene expression, suggesting a new form of cellular communication.

  • María Mittelbrunn
  • , Cristina Gutiérrez-Vázquez
  •  & Francisco Sánchez-Madrid